From: Does the sex of acute stroke patients influence the effectiveness of rt-PA?
Factors | Males (n = 199) | Females (n = 170) | P value |
---|---|---|---|
53.9% | 46.1% | ||
Age (years) | 67 ± 13 | 70 ± 14 | 0.014 |
Baseline NIHSS (mean ± SD) | 16 ± 6 | 17 ± 5 | 0.4 |
NIHSS: | 0.2 | ||
0-5 | 6 | 0 (0%) | |
6-10 | (3%) | 26 (15.3%) | |
11-15 | 29 (14.6%) | 42 (24.&%) | |
16-20 | 53 (26.6%) | 61 (35.9%) | |
>20 | 64 (32.2%) | 41 (24.1%) | |
Systolic BP (mean ± SD) | 157 ± 21 | 158 ± 23 | 0.7 |
Glucose (mean ± SD) | 140 ± 55 | 159 ± 88 | 0.012 |
Glucose >200 mg/dl | 19 (10%) | 34 (21.5%) | 0.004 |
Diabetes mellitus | 33/143 (23.1%) | 52/123 (42.3%) | 0.001 |
ASPECT score on CT | 8.4 ± 2 | 8.5 ± 1.4 | 0.6 |
Time from stroke onset to IV t-PA (mean ± SD) minutes (median ± SD) minutes | 143 ± 73 | 142 ± 41 | 0.9 |
142 ± 41 | 143 ± 73 | ||
Time from stroke onset to TCD exam: | 0.9 | ||
(mean ± SD) minutes | 140 ± 84 | 140 ± 64 | |
(median ± SD) minutes | 136 ± 4 | 134 ± 96 | |
Stroke TOAST classification: | 0.6 | ||
Large artery atherosclerosis | 53 (26.6%) | 39 (23.1%) | |
Cardio-embolism | 93 (46.7%) | 80 (47.3%) | |
Small vessel occlusion | 0 (0%) | 0 (0%) | |
Other: determined | 3 (1.5%) | 5 (3%) | |
Unknown | 50 (25.1%) | 45 (26.6%) | |
Type of occlusion: | 0.13 | ||
MCA M1 | 87 (44%) | 95 (56%) | |
MCA M2 | 62 (31%) | 38 (22%) | |
T. ICA | 6 (3%) | 10 (6%) | |
Tandem ICA/MCA | 37 (19%) | 24 (14%) | |
Basilar artery | 4 (2%) | 1 (0.6%) | |
Vertebral artery | 2 (1%) | 1 (0.6%) | |
PCA or ACA | 1 (0.5%) | 1 (0.6%) | |
TCD flow findings: | 0.6 | ||
Persistent occlusion | 73 (36.6%) | 71 (41.8%) | |
Partial recanalization | 58 (29.1%) | 46 (27%) | |
Compete recanalization | 68 (34.2%) | 53 (31.2%) | |
Time from IV tPA bolus to complete recanalization (mean ± SD) minutes | 134 ± 96 | 136 ± 74 | 0.8 |
Clinical deterioration following treatment improvement | 26 (13%) | 18 (11%) | 0.4 |
Arterial re-occlusion | 28 (14%) | 29 (17.1%) | 0.9 |
S ICH | 17 (8.5%) | 13 (7.6%) | 0.7 |
Good long-term outcome (mRS < at 3 months) | 78/160 (49%) | 65/142 (46%) | 0.6 |