Protocol for a randomized comparison of integrated versus consecutive dual task practice in Parkinson’s disease: the DUALITY trial

Table 3 Primary, secondary and tertiary outcome measures

	Outcome measures	Baseline 1	Baseline 2	Post-intervention	12 week follow-up
Primary outcome measure
DT gait performance	Gait velocity Stroop	x	x	x	x
Secondary outcome measures
DT gait performance	Cadence, Stride length Stroop	x	x	x	x
	Gait variability Stroop	x	x	x	x
	Gait velocity, Cadence, Stride length Digit	x	x	x	x
	Gait variability Digit	x	x	x	x
	Gait velocity, Cadence, Stride length Mobile	x	x	x	x
	Phone
	Gait variability Mobile Phone	x	x	x	x
ST gait performance	Gait velocity	x	x	x	x
	Cadence	x	x	x	x
	Stride length	x	x	x	x
	Gait variability measures	x	x	x	x
DT cognitive tasks	Reaction time digit	x	x	x	x
	Response time digit	x	x	x	x
	Errors digit	x	x	x	x
	Reaction time Stroop	x	x	x	x
	Errors Stroop	x	x	x	x
	Errors Mobile phone	x	x	x	x
ST cognitive tasks	Reaction time digit	x	x	x	x
	Response time digit	x	x	x	x
	Errors digit	x	x	x	x
	Reaction time Stroop	x	x	x	x
	Errors Stroop	x	x	x	x
	Errors Mobile phone	x	x	x	x
Tertiary outcome measures
Adverse effects	Number of falls	Weekly follow-up
Motor function	MDS-UPDRS III	x	x	x	x
	New FOGQ	x	x	x	x
	ABC	x	x	x	x
Cognitive function	Scopa-Cog	x	x	x	x
	Alternating fluency (ANT/AIT)	x	x	x	x
	FAB	x	-	-	-
Descriptors	Disease duration	x	-	-	-
	Medication dose	x	x	x	x
	Hoehn and Yahr stage	x	-	-	-
	MMSE	x	-	-	-
	MoCA	x	-	-	-
Quality of life	PDQ-39	x	x	x	x
Patient experience	Focus interview	-	-	-	x

DT: Dual task. ST: Single task. MDS-UPDRS part III: Unified Parkinson’s Disease Rating Scale – motor part. H-Y: Hoehn and Yahr stage. New FOGQ: new Freezing of Gait Questionnaire. ABC: Activities specific Balance Confidence scale. Scopa-Cog: Scales for Outcomes in Parkinson’s disease – cognitive. ANT: Alternating Names Test. AIT: Alternating Intakes test. MMSE: Mini Mental State Examination. MoCA: Montreal Cognitive Assessment. FAB: Frontal Assessment Battery. PDQ-39: Parkinson’s Disease Quality of Life Questionnaire.

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