Table 3 Details on the three cases of atrioventricular block (AVB) with onset after the first dose of fingolimod
Gender, age (case number) | Event | CV medical history | Concomitant medications | CV baseline assessment | Onset of event, hours post dose | HR at onset (bpm) | Outcome | Action taken |
|---|---|---|---|---|---|---|---|---|
Female, 24 | Second degree AVB, M1 | None | Topiramate | Normal ECG | 3 | 54 (arrhythmic) | Spontaneously resolved within 12 hours | Patient was hospitalized |
(Case 1) | HR: 67 bpm | |||||||
BP: 100/60 mmHg | ||||||||
Male, 29 | Second degree AVB, M1 | Cardiac murmur | None | Abnormal ECGa | 2 | 58 | Spontaneously resolved within 12 hours | Patient was hospitalized. Study drug discontinued |
(Case 2) | HR: 73 bpm | |||||||
BP: 130/90 mmHg | ||||||||
Female, 29 | First degree AVB | None | Trazodone | Normal ECG | 4 | 68 | Spontaneously resolved the day after | None |
(Case 3) | HR: 72 bpm, | |||||||
BP: 112/75 mmHg |