Table 2 Hazard ratios for subarachnoid haemorrhage per 1 standard deviation increase of leukocytes and in relation to sex-specific quartiles of leukocytes, for all participants and stratified by sex and smoking status

All

n

5110

4864

4794

5026

19794

SAH, n

15

23

27

30

95

HR (95% CI)

1

1.65 (0.86-3.16)

2.00 (1.06-3.76)

2.22 (1.19-4.12)

1.30 (1.09-1.54)

0.003

HR*

1

1.63 (0.85-3.14)

1.92 (1.00-3.66)

2.05 (1.06-3.96)

1.26 (1.05-1.53)

0.014

Men

n

4423

4227

4072

4361

17083

SAH, n

11

20

22

25

78

HR

1

1.95 (0.93-4.07)

2.27 (1.10-4.69)

2.53 (1.25-5.15)

1.28 (1.05-1.55)

0.013

HR*

1

1.99 (0.95-4.18)

2.35 (1.12-4.94)

2.63 (1.23-5.62)

1.28 (1.04-1.59)

0.021

Women

n

687

637

722

665

2711

SAH, n

4

3

5

5

17

HR

1

0.81 (0.18-3.64)

1.21 (0.32-4.51)

1.32 (0.36-4.93)

1.37 (0.95-1.97)

0.095

Never smokers

n

2563

1858

1317

665

6403

SAH, n

5

10

8

2

25

HR

1

2.80 (0.96-8.18)

3.18 (1.04-9.72)

1.60 (0.31-8.24)

1.31 (0.82-2.11)

0.257

Former smokers

n

1249

1085

783

420

3555

SAH, n

8

5

3

2

18

HR

1

0.74 (0.24-2.26)

0.62 (0.16-2.34)

0.81 (0.17-3.80)

0.93 (0.49-1.78)

0.824

Current smokers

n

1288

1908

2635

3913

9836

SAH, n

2

8

16

26

52

HR

1

2.72 (0.58-12.8)

3.88 (0.89-16.9)

4.47 (1.06-18.8)

1.33 (1.07-1.65)

0.010

HR*

1

2.73 (0.58-12.8)

3.91 (0.90-17.0)

4.51 (1.07-19.0)

1.32 (1.06-1.63)

0.011