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Table 3 NQO1 rs1800566 genotype and allelic variants in patients with multiple sclerosis (MS), and relation with the clinical evolutive type of MS

From: NQO1gene rs1800566 variant is not associated with risk for multiple sclerosis

 

BOUT ONSET MS (RELAPSING REMITTING PLUS SECONDARY PROGRESSIVE MS) N

Intergroup comparison values OR (95% CI), P

PRIMARY PROGRESSIVE MS N (%, 95% C.I.)

Intergroup comparison values OR (95% CI), P

CONTROLS N (%, 95% C.I.)

rs1800566 GENOTYPE C/C

153 (61.9; 55.9-68.0)

Reference

25 (58.1, 43.4-72.9)

Reference

195 (62.9, 57.5-68.3)

C/T

85 (34.4; 28.5-40.3)

1.04 (0.72-1.51); 0.822

14 (32.6, 18.6-46.6)

1.05 (0.52-2.11), 0.891

104 (33.5, 28.3-38.8)

T/T

9 (3.6; 1.3-6.0)

1.04 (0.39-2.79); 0.928

4 (9.3, 0.6-18.0)

2.84 (0.84-9.59), 0.081

11 (3.5, 1.5-5.6)

Total

247

 

43

 

310

Allele C

391 (79.1; 75.6-82.7)

Reference

64 (74.4, 65.2-83.6)

Reference

494 (79.7, 76.5-82.8)

Allele T

103 (20.9; 17.3-24.4)

1.03 (0.76-1.40); 0.829

22 (25.6, 16.4-34.8)

1.35 (0.80-2.27), 0.262

126 (20.3, 17.2-23.5)

Total alleles

494

 

86

 

620

  1. All subgroups were compared with control subjects. Major alleles and genotypes were assumed as reference values. P values correspond to logistic regression analyses.