Table 1 Summary of mean visual area CBF and reactivity in Fabry disease compared to controls together with the mean visual area resting and post stimulation CBF changes in the ERT Fabry and placebo groups following the double-blind, placebo-controlled randomized trial. All values are means ± standard deviation.
From: Enzyme replacement reverses abnormal cerebrovascular responses in Fabry disease
Cerebral Blood Flow [ml/min/100 g tissue] | Fabry Patients n = 26 | Control Subjects n = 10 | P value |
|---|---|---|---|
Rest | 25.7 ± 3.8 | 22.8 ± 2.9 | 0.019 |
Visual Activation | 29.43 ± 3.44 | 25.78 ± 2.45 | 0.002 |
Change with visual activation | 3.74 ± 2.91 | 3.0 ± 2.88 | 0.498 |
Cerebral Blood Flow change Post ERT or Placebo | Enzyme Replacement Group n = 14 | Placebo Group n = 11 | P value |
Change in resting rCBF | -2.3 ± 3.7 | 1.1 ± 4.2 | 0.050 |
Change in rCBF during visual activation | -1.75 ± 2.6 | 0.61 ± 5.08 | 0.184 |
Mean Visual Area Reactivity | 0.51 ± 3.41 | -0.47 ± 5.84 | 0.629 |