From: Enzyme replacement reverses abnormal cerebrovascular responses in Fabry disease
Global Cerebral Blood Flow [ml/min/100 g tissue] | Fabry Patients | Control Subjects | P value |
---|---|---|---|
Rest | 42.0 ± 4.9, n = 26 | 39.2 ± 4.8, n = 10 | 0.136 |
Post-acetazolamide 20 minute time point | 57.5 ± 8.9, n = 26 | 57.9 ± 7.9, n = 9 | 0.969 |
Post-acetazolamide 30 minute time point | 56.9 ± 7.9, n = 26 | 54.2 ± 8.6, n = 10 | 0.406 |
Cerebral Blood Flow change Post-ERT or Placebo | Enzyme Replacement Group | Placebo Group | P value |
Resting Cerebral Blood Flow | -3.5 ± 4.6, n = 14 | 1.3 ± 5.1, n = 11 | 0.026 |
Post-acetazolamide 20 minute time point | -3.9 ± 7.9, n = 13 | 0.5 ± 10.8, n = 9 | 0.314 |
Post-acetazolamide 30 minutes time point | -7.0 ± 5.5, n = 13 | 1.1 ± 9.2, n = 9 | 0.036 |