Skip to main content

Table 1 Association Studies of Thrombosis Genes in Ischemic and Carotid Atherosclerosis

From: The Ischemic Stroke Genetics Study (ISGS) Protocol

Gene

Reference

Polymorphism

Cases, n; controls, n

Results

Factor V

Catto et al., 1995 [56]; Catto et al., 1996 [57]

G1691A

348; 247

Negative

 

Kontula et al., 1995 [58]

G1691A

236; 137

Negative

 

Ridker et al., 1995 [15]

G1691A

209; 209

Negative

 

Martinelli et al., 1997 [59]

G1691A

155; 155

Negative

 

Press et al., 1996 [60]

G1691A

116; 54/161/287

Negative

 

van der Bom et al., 1996 [61]

G1691A

112; 222

Negative

 

Longstreth et al., 1998 [62]

G1691A

106; 391

Negative

 

Halbmayer et al., 1997 [63]

G1691A

229; 71

Negative

 

Markus et al., 1996 [64]

G1691A

180; 80

Negative

Factor VII

Nishiuma et al., 1997 [65]

R353Q

137; 83/87

Negative

 

Heywood et al., 1997 [66]

R353Q

286; 198

Negative

 

Corral et al., 1998 [67]

R353Q/323A2

104; 104

Negative

Factor XIII

Catto et al., 1998 [68]

Val34Leu

529; 437

Negative

β-Fibrinogen

Schmidt et al., 1998 [11]

C148T

399

Positive

 

Carter et al., 1997 [12]

G448A

305; 197

Positive

 

Kessler et al., 1997 [10]

G455A

227; 225

Positive

GPIa/IIa

Carlsson et al., 1999 [13]

C807T

227; 170

Positive

 

Carlsson et al., 1997 [69]

HPA-5

218; 165/321

Negative

GPIbα

Gonzalez-Conejero et al., 1998 [14]

VNTR

104; 104

Positive

  

HPA-2

104; 104

Positive

GPIIb/IIIa

Carter et al., 1998 [16]

P1A2

505; 402

Positive

 

Ridker et al., 1997 [70]

P1A2

209; 209

Negative

 

Carlsson et al., 1997 [69]

HPA-1

218; 165/321

Negative

  

HPA-3

218; 165/321

Negative

PAI 1

Catto et al., 1997 [71]

4G/5G

421; 172

Negative

Prothrombin

Longstreth et al., 1998 [62]

G20210A

106; 391

Negative

 

Poort et al., 1996 [72]

G20210A

104; 104

Negative

 

Martinelli et al., 1997 [59]

G20210A

155; 155

Negative

 

Ridker et al., 1999 [73]

G20210A

259; 1,744

Negative

  1. GP, glycoprotein; PAI, plasminogen activator inhibitor.