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Table 1 Association Studies of Thrombosis Genes in Ischemic and Carotid Atherosclerosis

From: The Ischemic Stroke Genetics Study (ISGS) Protocol

Gene Reference Polymorphism Cases, n; controls, n Results
Factor V Catto et al., 1995 [56]; Catto et al., 1996 [57] G1691A 348; 247 Negative
  Kontula et al., 1995 [58] G1691A 236; 137 Negative
  Ridker et al., 1995 [15] G1691A 209; 209 Negative
  Martinelli et al., 1997 [59] G1691A 155; 155 Negative
  Press et al., 1996 [60] G1691A 116; 54/161/287 Negative
  van der Bom et al., 1996 [61] G1691A 112; 222 Negative
  Longstreth et al., 1998 [62] G1691A 106; 391 Negative
  Halbmayer et al., 1997 [63] G1691A 229; 71 Negative
  Markus et al., 1996 [64] G1691A 180; 80 Negative
Factor VII Nishiuma et al., 1997 [65] R353Q 137; 83/87 Negative
  Heywood et al., 1997 [66] R353Q 286; 198 Negative
  Corral et al., 1998 [67] R353Q/323A2 104; 104 Negative
Factor XIII Catto et al., 1998 [68] Val34Leu 529; 437 Negative
β-Fibrinogen Schmidt et al., 1998 [11] C148T 399 Positive
  Carter et al., 1997 [12] G448A 305; 197 Positive
  Kessler et al., 1997 [10] G455A 227; 225 Positive
GPIa/IIa Carlsson et al., 1999 [13] C807T 227; 170 Positive
  Carlsson et al., 1997 [69] HPA-5 218; 165/321 Negative
GPIbα Gonzalez-Conejero et al., 1998 [14] VNTR 104; 104 Positive
   HPA-2 104; 104 Positive
GPIIb/IIIa Carter et al., 1998 [16] P1A2 505; 402 Positive
  Ridker et al., 1997 [70] P1A2 209; 209 Negative
  Carlsson et al., 1997 [69] HPA-1 218; 165/321 Negative
   HPA-3 218; 165/321 Negative
PAI 1 Catto et al., 1997 [71] 4G/5G 421; 172 Negative
Prothrombin Longstreth et al., 1998 [62] G20210A 106; 391 Negative
  Poort et al., 1996 [72] G20210A 104; 104 Negative
  Martinelli et al., 1997 [59] G20210A 155; 155 Negative
  Ridker et al., 1999 [73] G20210A 259; 1,744 Negative
  1. GP, glycoprotein; PAI, plasminogen activator inhibitor.