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Table 1 Description, chromosomal location and microsatellite markers for the candidate loci that were investigated.

From: A linkage study of candidate loci in familial Parkinson's Disease

Locus Description Chromosome Map Reference
PARK3            Parkinson's disease susceptibility 2p13 D2S441-1.6cM-D2S2113-1.4cM-D2S291-0.5cM-D2S2111-0.1cM-D2S2109-1.9cM-D2S1394 Gasser et al, 1998 [9]
Nurr1 Steroid receptor 2q22-23 D2S142-0.7cM-D2S284 Mages et al, 1994 [39]
FET1 Familial essential tremor 3q13 D3S1278-9.3cM-D3S1267 Gulcher et al, 1997 [30]
DAT1 Dopamine transporter 5p15 DAT1VNTR-5.5cM-D5S1455-8cM-D5S817 Vandenbergh et al, 1992 [40]
GDNF Glial cell line-derived neurotrophic factor 5p12-13 D5S674-4.8cM-D5S426-0.6cM-D5S395 Schindelhauer et al, 1995 [41]
Synphilin-1 Interacts with α-synuclein 5q23 D5S492-13.8cM-D5S657 Engelender et al, 1999 [25]
Parkin Juvenile recessive Parkinson's disease 6q25-27 D6S305-0.3cM-D6S411 Kitada et al, 1998 [5]
Ret Receptor of GDNF 10q11.2 D10S141 Ishizaka et al, 1989 [42]
BDNF Brain-derived neurotrophic factor 11p13 D11S1324-3.4cM-D11S914-0.3cM-D11S1322 Maisonpierre et al, 1991 [43]
DRD Dopa-responsive dystonia 14q22 D14S583-0.3cM-D14S587-0.3cM-D14S301 Ichinose et al, 1994 [3]