A linkage study of candidate loci in familial Parkinson's Disease

BMC Neurology

Table 1 Description, chromosomal location and microsatellite markers for the candidate loci that were investigated.

Locus	Description	Chromosome	Map	Reference
PARK3	Parkinson's disease susceptibility	2p13	D2S441-1.6cM-D2S2113-1.4cM-D2S291-0.5cM-D2S2111-0.1cM-D2S2109-1.9cM-D2S1394	Gasser et al, 1998 [9]
Nurr1	Steroid receptor	2q22-23	D2S142-0.7cM-D2S284	Mages et al, 1994 [39]
FET1	Familial essential tremor	3q13	D3S1278-9.3cM-D3S1267	Gulcher et al, 1997 [30]
DAT1	Dopamine transporter	5p15	DAT1VNTR-5.5cM-D5S1455-8cM-D5S817	Vandenbergh et al, 1992 [40]
GDNF	Glial cell line-derived neurotrophic factor	5p12-13	D5S674-4.8cM-D5S426-0.6cM-D5S395	Schindelhauer et al, 1995 [41]
Synphilin-1	Interacts with α-synuclein	5q23	D5S492-13.8cM-D5S657	Engelender et al, 1999 [25]
Parkin	Juvenile recessive Parkinson's disease	6q25-27	D6S305-0.3cM-D6S411	Kitada et al, 1998 [5]
Ret	Receptor of GDNF	10q11.2	D10S141	Ishizaka et al, 1989 [42]
BDNF	Brain-derived neurotrophic factor	11p13	D11S1324-3.4cM-D11S914-0.3cM-D11S1322	Maisonpierre et al, 1991 [43]
DRD	Dopa-responsive dystonia	14q22	D14S583-0.3cM-D14S587-0.3cM-D14S301	Ichinose et al, 1994 [3]

ISSN: 1471-2377