TY - JOUR AU - Saft, Carsten AU - Lauter, Thorsten AU - Kraus, Peter H. AU - Przuntek, Horst AU - Andrich, Juergen E. PY - 2006 DA - 2006/02/28 TI - Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series JO - BMC Neurology SP - 11 VL - 6 IS - 1 AB - Chorea in Huntington's Disease (HD) is usually treated with antidopaminergic neuroleptics like haloperidol, olanzapine and tiaprid or dopamine depleting drugs like tetrabenazine. Some patients with hyperkinesia, however, react to treatment with antidopaminergic drugs by developing extrapyramidal side effects. In earlier studies valproic acid showed no beneficial effect on involuntary choreatic movements. Myoclonus is rare in HD and is often overseen or misdiagnosed as chorea. SN - 1471-2377 UR - https://doi.org/10.1186/1471-2377-6-11 DO - 10.1186/1471-2377-6-11 ID - Saft2006 ER -