Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis

BMC Neurology

Table 2 Clinical scores

#	RUE (75)	LUE (75)	RLE (45)	LLE (45)	UE (150)	LE (90)	all E. (240)	fasc. (0–42)	atr. (0–30)	bulb. (0–14)	Bab. (0–2)	spast. (0–32)	refl. (0–13)	ALSFRS-R PR/mth(6)	ALSFRS-R PR/mth(t)
1	68	69	41	41	137	82	219	5	7	2	0	0	0	0.5	0.2
2	75	64	31	27	139	58	197	7	4	0	0	0	0	1.8	0.8
3	64	62	45	45	126	90	216	15	8	0	2	0	12	1.2	0.4
4	75	73	45	42	148	87	235	10	2	2	2	4	4	0.7	0.4
5	72	75	26	16	147	42	189	15	8	0	1	0	6	0.7	0.4
6	67	59	14	13	126	27	153	4	6	0	0	0	6	1.2	0.5
7	74	75	26	23	149	49	198	12	2	0	0	0	0	0.2	0.1
8	70	71	45	45	141	90	231	1	2	4	2	0	12	1.0	0.5
9	60	60	36	39	120	75	195	17	6	0	0	0	0	1.0	0.3
10	63	73	45	45	136	90	226	6	5	4	0	0	12	0.7	0.4
11	54	55	45	45	109	90	199	4	6	0	2	0	0	0.3	0.4
12	58	43	38	38	101	76	177	11	10	3	2	0	6	0.5	0.6
13	58	57	45	45	115	90	205	8	7	2	2	0	5	1.5	0.5
14	70	71	22	37	141	59	200	7	6	0	2	2	12	1.7	0.4
15	75	75	45	45	150	90	240	1	0	3	0	0	11	0.2	0.3
16	61	71	44	44	132	88	220	9	8	0	1	0	0	0.0	0.0
17	69	71	40	41	140	81	221	6	4	3	2	4	6	1.0	0.3
mean	66.6	66.1	37.2	37.1	132.8	74.4	207.1	8.1	5.4	1.4	1.1	0.6	5.4	0.82	0.38
± S.D.	6.7	9.0	9.9	10.6	14.6	19.9	22.3	4.7	2.7	1.6	1.0	1.4	4.9	0.54	0.20
Δ _norm (%)	-11%	-12%	-17%	-18%	-11%	-17%	-14%	19%	18%	10%	53%	2%	42%

MRC sum scores were used to describe muscle strength for right upper (RUE), left upper (LUE), right lower (RLE), left lower (LLE), upper (UE) and lower (LE) and all extremities (all E., see methods); disease related strength reduction is displayed as percent in the lower row. Sum scores of fasciculations, atrophy, bulbar signs, Babinski sign, spasticity and reflexes are represented as pathologic increase; the lower row values show percent of maximal pathologic scores. ALSFRS progression rates per month are calculated for the 6 months prior to MRI [PR/mth(6)] and the total disease duration [PR/mth(t)].

ISSN: 1471-2377