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Table 2 Top 20 upregulated genes in PBMC following exposue to IFNβ

From: Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNβ-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNβ-related adverse effects in multiple sclerosis

No.

Cy5/Cy3 ratio

Symbol

GenBank

Gene name

at 3 hours

1

188.50

IFIT1

X03557

interferon-induced protein with tetratricopeptide repeats 1 (IFI56)

2

149.82

SCYB11

AF030514

chemokine (C-X-C motif) ligand 11 (CXCL11, IP-9, I-TAC)

3

81.81

ISG15

M13755

interferon-stimulated gene ISG15 (G1P2)

4

67.84

IFIT4

AF083470

interferon-induced protein with tetratricopeptide repeats 4 (IFI60)

5

66.38

MX1

M30817

myxovirus resistance protein 1 (MXA)

6

64.43

SCYB10

X02530

chemokine (C-X-C motif) ligand 10 (CXCL10, IP-10)

7

55.01

SCYA8

Y10802

chemokine (C-C motif) ligand 8 (CCL8, MCP2)

8

36.88

SCYB9

X72755

chemokine (C-X-C motif) ligand 9 (CXCL9, MIG)

9

35.14

TNFSF10

U37518

tumor necrosis factor superfamily, member 10 (TRAIL)

10

32.86

MX2

M30818

myxovirus resistance protein 2 (MXB)

11

21.99

IFI27

X67325

interferon alpha-inducible protein 27

12

21.98

G1P3

X02492

interferon alpha-inducible protein (IFI6-16), isoform a

13

19.26

ISG20

U88964

interferon-stimulated gene ISG20

14

19.12

STAT1

M97935

signal transducer and activator of transcription 1, isoform alpha

15

13.71

IRF7

U53830

interferon-regulatory factor 7, isoform alpha

16

13.44

CCNA1

U66838

cyclin A1

17

12.72

IL6

M14584

interleukin 6

18

10.86

IL1RN

X53296

interleukin 1 receptor antagonist, isoform 1

19

10.47

SCYA2

S71513

chemokine (C-C motif) ligand 2 (CCL2, MCP1)

20

9.91

STAT2

M97934

signal transducer and activator of transcription 2

at 24 hours

1

193.19

SCYA8

Y10802

chemokine (C-C motif) ligand 8 (CCL8, MCP2)

2

124.77

IFIT1

X03557

interferon-induced protein with tetratricopeptide repeats 1 (IFI56)

3

107.21

IFI27

X67325

interferon alpha-inducible protein 27

4

70.51

ISG15

M13755

interferon-stimulated gene ISG15 (G1P2)

5

53.22

SCYB11

AF030514

chemokine (C-X-C motif) ligand 11 (CXCL11, IP-9, I-TAC)

6

38.07

MX1

M30817

myxovirus resistance protein 1 (MXA)

7

37.95

IFIT4

AF083470

interferon-induced protein with tetratricopeptide repeats 4 (IFI60)

8

31.56

SCYB10

X02530

chemokine (C-X-C motif) ligand 10 (CXCL10, IP-10)

9

23.65

G1P3

X02492

interferon alpha-inducible protein (IFI6-16), isoform a

10

23.10

TNFSF10

U37518

tumor necrosis factor superfamily, member 10 (TRAIL)

11

21.31

MX2

M30818

myxovirus resistance protein 2 (MXB)

12

20.68

PDGFRL

D37965

platelet-derived growth factor receptor-like protein

13

15.95

CD80

M27533

CD80 antigen (B7-1)

14

13.99

IRF7

U53830

interferon-regulatory factor 7, isoform alpha

15

13.93

IL1RN

X53296

interleukin 1 receptor antagonist, isoform 1

16

13.31

ISG20

U88964

interferon-stimulated gene ISG20

17

11.81

IFITM1

J04164

interferon induced transmembrane protein 1 (IFI17)

18

8.67

SCYA2

S71513

chemokine (C-C motif) ligand 2 (CCL2, MCP1)

19

8.54

IL6

M14584

interleukin 6

20

8.51

IL8RB

L19593

interleukin 8 receptor beta (CXCR2)

  1. Top 20 upregulated genes in PBMC of the subject #1 (a 46 year-old healthy man) by exposure to 50 ng/ml recombinant human IFNβ for 3 or 24 hours are listed with Cy5/Cy3 signal intensity ratio, gene symbol, GenBank accession number, and gene name. In vivo IRGs in T cells and non-T cells of RRMS patients reported previously (Ref. 16) are underlined.
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BMC Neurology

ISSN: 1471-2377

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