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Table 2 Top 20 upregulated genes in PBMC following exposue to IFNβ

From: Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNβ-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNβ-related adverse effects in multiple sclerosis

No. Cy5/Cy3 ratio Symbol GenBank Gene name
at 3 hours
1 188.50 IFIT1 X03557 interferon-induced protein with tetratricopeptide repeats 1 (IFI56)
2 149.82 SCYB11 AF030514 chemokine (C-X-C motif) ligand 11 (CXCL11, IP-9, I-TAC)
3 81.81 ISG15 M13755 interferon-stimulated gene ISG15 (G1P2)
4 67.84 IFIT4 AF083470 interferon-induced protein with tetratricopeptide repeats 4 (IFI60)
5 66.38 MX1 M30817 myxovirus resistance protein 1 (MXA)
6 64.43 SCYB10 X02530 chemokine (C-X-C motif) ligand 10 (CXCL10, IP-10)
7 55.01 SCYA8 Y10802 chemokine (C-C motif) ligand 8 (CCL8, MCP2)
8 36.88 SCYB9 X72755 chemokine (C-X-C motif) ligand 9 (CXCL9, MIG)
9 35.14 TNFSF10 U37518 tumor necrosis factor superfamily, member 10 (TRAIL)
10 32.86 MX2 M30818 myxovirus resistance protein 2 (MXB)
11 21.99 IFI27 X67325 interferon alpha-inducible protein 27
12 21.98 G1P3 X02492 interferon alpha-inducible protein (IFI6-16), isoform a
13 19.26 ISG20 U88964 interferon-stimulated gene ISG20
14 19.12 STAT1 M97935 signal transducer and activator of transcription 1, isoform alpha
15 13.71 IRF7 U53830 interferon-regulatory factor 7, isoform alpha
16 13.44 CCNA1 U66838 cyclin A1
17 12.72 IL6 M14584 interleukin 6
18 10.86 IL1RN X53296 interleukin 1 receptor antagonist, isoform 1
19 10.47 SCYA2 S71513 chemokine (C-C motif) ligand 2 (CCL2, MCP1)
20 9.91 STAT2 M97934 signal transducer and activator of transcription 2
at 24 hours
1 193.19 SCYA8 Y10802 chemokine (C-C motif) ligand 8 (CCL8, MCP2)
2 124.77 IFIT1 X03557 interferon-induced protein with tetratricopeptide repeats 1 (IFI56)
3 107.21 IFI27 X67325 interferon alpha-inducible protein 27
4 70.51 ISG15 M13755 interferon-stimulated gene ISG15 (G1P2)
5 53.22 SCYB11 AF030514 chemokine (C-X-C motif) ligand 11 (CXCL11, IP-9, I-TAC)
6 38.07 MX1 M30817 myxovirus resistance protein 1 (MXA)
7 37.95 IFIT4 AF083470 interferon-induced protein with tetratricopeptide repeats 4 (IFI60)
8 31.56 SCYB10 X02530 chemokine (C-X-C motif) ligand 10 (CXCL10, IP-10)
9 23.65 G1P3 X02492 interferon alpha-inducible protein (IFI6-16), isoform a
10 23.10 TNFSF10 U37518 tumor necrosis factor superfamily, member 10 (TRAIL)
11 21.31 MX2 M30818 myxovirus resistance protein 2 (MXB)
12 20.68 PDGFRL D37965 platelet-derived growth factor receptor-like protein
13 15.95 CD80 M27533 CD80 antigen (B7-1)
14 13.99 IRF7 U53830 interferon-regulatory factor 7, isoform alpha
15 13.93 IL1RN X53296 interleukin 1 receptor antagonist, isoform 1
16 13.31 ISG20 U88964 interferon-stimulated gene ISG20
17 11.81 IFITM1 J04164 interferon induced transmembrane protein 1 (IFI17)
18 8.67 SCYA2 S71513 chemokine (C-C motif) ligand 2 (CCL2, MCP1)
19 8.54 IL6 M14584 interleukin 6
20 8.51 IL8RB L19593 interleukin 8 receptor beta (CXCR2)
  1. Top 20 upregulated genes in PBMC of the subject #1 (a 46 year-old healthy man) by exposure to 50 ng/ml recombinant human IFNβ for 3 or 24 hours are listed with Cy5/Cy3 signal intensity ratio, gene symbol, GenBank accession number, and gene name. In vivo IRGs in T cells and non-T cells of RRMS patients reported previously (Ref. 16) are underlined.