Table 3 Top 20 downregulated genes in PBMC following exposue to IFNβ
No. | Cy5/Cy3 ratio | Symbol | GenBank | Gene name |
|---|---|---|---|---|
at 3 hours | ||||
1 | 0.29 | RGS14 | NM_006480 | regulator of G-protein signaling 14 |
2 | 0.30 | FOS | NM_005252 | cellular oncogene c-fos |
3 | 0.31 | SCYB2 | NM_002089 | chemokine (C-X-C motif) ligand 2 (GRO2, MIP2A) |
4 | 0.41 | PPARG2 | U63415 | peroxisome proliferative activated receptor gamma, isoform 2 |
5 | 0.41 | TNFSF11 | NM_003701 | tumor necrosis factor ligand superfamily, member 11 (RANKL), isoform 1 |
6 | 0.42 | ABCC4 | NM_005845 | ATP-binding cassette, subfamily C, member 4 (MRP4) |
7 | 0.42 | MERTK | NM_006343 | c-mer proto-oncogene tyrosine kinase |
8 | 0.42 | TGFBR3 | NM_003243 | transforming growth factor beta receptor III (betaglycan) |
9 | 0.44 | ATP2B1 | J04027 | ATPase, Ca++ transporting, plasma membrane 1, isoform 1b |
10 | 0.45 | SCYB1 | NM_001511 | chemokine (C-X-C motif) ligand 1 (GRO1, MGSA) |
11 | 0.45 | IL8 | NM_000584 | interleukin 8 (SCYB8, CXCL8) |
12 | 0.45 | TRAF5 | NM_004619 | TNF receptor-associated factor 5, variant 1 |
13 | 0.47 | CD3G | NM_000073 | CD3G antigen, gamma polypeptide |
14 | 0.47 | IL1A | NM_000575 | interleukin 1 alpha |
15 | 0.47 | TCFL5 | NM_006602 | transcription factor-like 5 |
16 | 0.48 | LAT | AF036905 | linker for activation of T cells, isoform b |
17 | 0.48 | HNMT | U08092 | histamine N-methyltransferase, isoform 1 |
18 | 0.48 | SLC3A1 | NM_000341 | solute carrier family 3, member 1 |
19 | 0.49 | MGST1 | NM_145764 | microsomal glutathione S-transferase 1, variant 1d |
20 | 0.49 | TNFSF8 | NM_001244 | tumor necrosis factor ligand superfamily, member 8 (CD30L) |
at 24 hours | ||||
1 | 0.18 | ABCC3 | AF083552 | ATP-binding cassette, subfamily C, member 3, isoform MRP3 |
2 | 0.20 | FOS | NM_005252 | cellular oncogene c-fos |
3 | 0.30 | ALDH2 | NM_000690 | aldehyde dehydrogenase 2 family |
4 | 0.30 | TPST1 | NM_003596 | tyrosylprotein sulfotransferase 1 |
5 | 0.31 | CD9 | NM_001769 | CD9 antigen |
6 | 0.34 | NRG1 | NM_013962 | neuregulin 1, isoform GGF2 |
7 | 0.35 | TLR5 | NM_003268 | toll-like receptor 5 |
8 | 0.36 | PTGS1 | NM_000962 | prostaglandin-endoperoxide synthase 1 (COX1), isoform 1 |
9 | 0.37 | MGST2 | NM_002413 | microsomal glutathione S-transferase 2 |
10 | 0.38 | ITGAM | NM_000632 | integrin, alpha M (CD11B, MAC-1, CR3A) |
11 | 0.38 | SCYA24 | NM_002991 | chemokine (C-C motif) ligand 24 (eotaxin 2) |
12 | 0.38 | CYP27A1 | NM_000784 | cytochrome P450, family 27, subfamily A, polypeptide 1 (CTX) |
13 | 0.39 | ALDH1A1 | NM_000689 | aldehyde dehydrogenase 1 family, member A1 |
14 | 0.39 | MYCL1 | NM_005376 | v-myc myelocytomatosis viral oncogene homolog 1 (LMYC) |
15 | 0.41 | ATP6AP2 | NM_005765 | ATPase, H+ transporting, lysosomal accessory protein 2 (ATP6M8-9) |
16 | 0.44 | PRKCG | NM_002739 | protein kinase C gamma |
17 | 0.45 | ATP2B1 | J04027 | ATPase, Ca++ transporting, plasma membrane 1, isoform 1b |
18 | 0.46 | AP1S2 | NM_003916 | adaptor-related protein complex 1, sigma 2 subunit |
19 | 0.47 | NR6A1 | NM_001489 | nuclear receptor subfamily 6, group A, member 1 (RTR), isoform 2 |
20 | 0.47 | GCG | NM_173916 | glucagon |