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Table 4 Functional classification of IFNβ-upregulated genes in PBMC

From: Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNβ-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNβ-related adverse effects in multiple sclerosis

Categories Number of genes Gene symbols (alternative symbols or names)
1 Conventional IFN-response markers 12 IFIT1 (IFI56), ISG15 (G1P2), IFIT4 (IFI60), MX1 (MXA), MX2 (MXB), IFI27, G1P3 (IFI6-16), ISG20, IFI16, IFITM1 (IFI17), IFITM3 (1-8U), ABCB2 (TAP1)
2 Components of IFN-signaling pathways 12 STAT1, IRF7, STAT2, JAK2, IRF2, ISGF3G (IRF9), MYD88, IRF8, STAT3, JAK3, IRF1, TLR3
3 Chemokines and receptors 11 SCYB11 (CXCL11, I-TAC), SCYB10 (CXCL10, IP-10), SCYA8 (CCL8, MCP2), SCYB9 (CXCL9, MIG), SCYA2 (CCL2, MCP1), CCR5, SCYA4 (CCL4, MIP1B), IL8RB (CXCR2), SCYA3 (CCL3, MIP1A), SCYA19 (CCL19, MIP3B), SCYA13 (CCL13, MCP4)
4 Cytokines, growth factors, and receptors 17 IL6, ILRN (IL-1 receptor antagonist), IL1R2, IL15RA, IL15, SPP1 (osteopontin), CSF1, IL12RB2, TNF (TNFA), IL2RB, IFNG, NTRK1 (TRKA), PDGFRL, TNFAIP6, KITLG (SCF), IL10, IL3RA
5 Apotosis, DNA damage, and cell cycle regulators 29 TNFSF10 (TRAIL), CASP10, BAG1, TNFRSF6 (FAS), CASP4, TRADD, GZMA, CASP7, RIPK2, MAD, RIPK1, CFLAR (FLIP), RELA, STK3, CASP1, TNFSF6 (FASL), PARP4, TANK (I-TRAF), POLE2, LMNB1, E2F2, CCNA1 (cyclin A1), CDKN1A (p21), PPP1R15A (GADD34), CASP3, CDKN1C (p57), CDK5R2 (p39), TERF1, NBS1 (nibrin)
6 Heat shock proteins 9 HSPA6 (HSP70B'), HSJ2 (HSPF4), HSPA1A (HSP70-1), HSPA1B (HSP70-2), HSPCA (HSP90A), HSPA5 (GRP78), HSPA1L (HSP70-HOM), HSPA8 (HSC70), HSPB1 (HSP27)
7 Costimulatory and adhesion molecules 7 CD80 (B7-1), SELL (selectin L), TNFRSF5 (CD40), CD163, CD86 (B7-2), HLA-DRA, FCER1G
  1. The upregulated IRGs in PBMC listed in Additional files 3 and 5 were classified into seven functional categories.