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Table 2 Contingency table and performance values of the 14-3-3 test in a population of clinically suspected sCJD cases

From: Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

  

All cases,n = 672

Final diagnosis

sCJD f

non-sCJD f

14-3-3 result

Pos.

155 [67]

15

 

Neg.

22 [8]

480

Performance values (%)

  

PPV

91.2 (85.6–94.8)

NPV

95.6 (93.3–97.2)

Sensitivity

87.6 (81.6–91.9)

Specificity

96.9 (94.9–98.2)

Efficiency

94.5 (92.5–96.0)

Prevalence

26.3 (23.2–29.8)

  1. sCJDf includes both probable (WHO's criteria without the inclusion of the 14-3-3 test results) and definite cases at final diagnosis. Definite cases are shown in square brackets. Confidence intervals at 95% level are shown in parentheses.