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Table 2 Contingency table and performance values of the 14-3-3 test in a population of clinically suspected sCJD cases

From: Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

   All cases,n = 672
Final diagnosis sCJD f non-sCJD f
14-3-3 result Pos. 155 [67] 15
  Neg. 22 [8] 480
Performance values (%)   
PPV 91.2 (85.6–94.8)
NPV 95.6 (93.3–97.2)
Sensitivity 87.6 (81.6–91.9)
Specificity 96.9 (94.9–98.2)
Efficiency 94.5 (92.5–96.0)
Prevalence 26.3 (23.2–29.8)
  1. sCJDf includes both probable (WHO's criteria without the inclusion of the 14-3-3 test results) and definite cases at final diagnosis. Definite cases are shown in square brackets. Confidence intervals at 95% level are shown in parentheses.