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Table 3 Age at onset, survival time, lumbar puncture (LP) timing, presence of PSWCs in EEG, and genotype at codon 129 of PRNP gene of 14-3-3-positive and 14-3-3-negative sCJD f patients

From: Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

14-3-3 result

Age at onset, years

Survival time, months

Time from onset to LP, months

Time from LP to death, months

PSWCs in EEG, %

M129V, %

Positive

69.8 (45.1–86.9), n= 144

4.7 (0.5–48.8),

n= 138

2.6 (0.7–27.2),

n= 125

1.2 (0–30.8),

n= 119

83.9%, n= 112

68.0%MM, 15.5%MV, 16.5%VV, n= 103

Negative

73.4 (59.1–82.3), n= 21

5.4 (0.4–29.9),

n= 15

2.9 (0.2–13.9),

n= 17

1.3 (0–26.8), n= 14

81.8%, n= 22

80.0%MM, 20.0%MV, 0%VV, n= 15

  1. sCJD f includes both probable and definite cases. The data of age, survival time, and LP timing correspond to median and range values.