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Table 4 Contingency tables and performance of the 14-3-3 test according to the initial clinical classification

From: Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

   Probable CJD, i n= 115 Possible CJD, i n= 73 non-sCJD, i n= 484
   Initial diagnosis
Final diagnosis sCJD f non-sCJD f sCJD f non-sCJD f sCJD f non-sCJD f
14-3-3 result Pos. 90 [36] 2 56 [27] 2 9 [4] 11
  Neg. 17 [7] 6 5 [1] 10 0 464
Performance values (%)       
PPV 97.8 (91.6–99.6) 96.5 (87.0–99.4) 45.0 (23.8–68.0)
NPV 26.1 (11.1–48.7) 66.6 (38.7–87.0) 100 (99.0–100.0)
Sensitivity 84.1 (75.5–90.2) 91.8 (81.2–96.9) 100 (62.9–100.0)
Specificity 75.0 (35.5–95.5) 83.3 (50.9–97.1) 97.7 (95.8–98.8)
Efficiency 83.5 (75.6–89.3) 90.4 (81.3–95.6) 97.7 (95.9–98.8)
Prevalence 93.0 (86.7–96.7) 83.6 (73.3–90.5) 1.9 (0.9–3.6)
  1. sCJDf includes both probable (WHO's criteria without the inclusion of the 14-3-3 test results) and definite cases at final diagnosis. Definite cases are shown in square brackets. Confidence intervals at 95% level are shown in parentheses.