Brain regions essential for improved lexical access in an aged aphasic patient: a case report

BMC Neurology

Table 2 General activation pattern of the patient during picture naming for different response types. Contrasts included correct responses > fixation; semantic paraphasias > fixation; neologisms > fixation (cluster threshold p < .01, k>50, FWE-corrected; voxel threshold p < .001, uncorrected).

			Correct > Fixation				SP > Fixation				Neo > Fixation
Region	Hemi	BA	x	y	z	Z	x	y	z	Z	x	y	z	Z
OCCIPITAL
Middle Occipital	R	19	33	-89	21	>9	36	-86	21	>8	36	-86	21	>11
	L	19					-39	-78	12	4.4
	R	18	24	-95	19	>7
	L	18	-18	-98	19	5.3
Inferior Occipital	L	19					-39	-79	-1	4.8
Fusiform Gyrus	R	18	27	-83	-21	6.3					30	-83	-21	7.6
Lingual Gyrus	R	17	-21	-90	-3	5.2
	L	17					-21	-88	-3	5.7
Cuneus	R	19					27	-86	35	6.7	27	-86	35	>9
Uncus	L	36					-24	-4	-28	6.8
TEMPORAL
Middle Temporal	R	19	45	-81	18	>9	45	-81	18	7.7	45	-81	18	>10
	R	21					53	-21	-4	6.0	53	-20	-1	7.6
Superior Temporal	R	38					30	19	-36	6.6
	R	22					48	-35	5	6.2	48	-29	1	6.8
	L	22					-65	-3	0	5.4
FRONTAL
Precentral	R	4	12	-31	71	7.4
	L	6					-62	1	28	6.6
Inferior Frontal	R	13*	39	27	7	5.1
	L	47	-24	29	-6	5.7
	L						-53	38	1	4.2
Middle Frontal	R	10	45	48	20	4.6
	R	6					36	-6	61	6.6
	L	11	-27	38	-4	4.9
PARIETAL
Postcentral	R	3	12	-37	68	7.5
Inferior Parietal	L	40									-39	-47	47	4.0
Superior Parietal	L	7									-30	-49	61	5.7
Precuneus	L	7									-30	-47	49	5.1
LIMBIC LOBE AND SUBCORTICAL STRUCTURES
Limbic (Uncus)	R	38	-27	4	-33	4.5
	R	34					12	-1	-25	6.2
	L	36	-21	-2	-30	4.8					-24	-4	-28	6.9
	L	20	-30	-19	-29	4.9
Para-hippocal	L	36					-30	-28	-26	5.6
Thalamus	R						12	-15	1	5.7
Globus Pallidus	R		24	-9	0	6.9
Putamen	L		-15	11	-11	3.5

SP = semantic paraphasias, Neo = neologisms; Hemi = Hemisphere; R = right, L = left; BA = Brodman Area; x/y/z = coordinates according to Talairach and Tournoux [36], Z = z-scores of significant voxels within significant clusters are reported (p < .001, k>50, corrected).
* The strongest activation in the cluster that includes the right IFG (total cluster size: k = 218, number of voxels located in the right IFG: k = 148) was found in BA 13 (k = 31), closer inspection of this cluster revealed addional activation in BA 45 (29,26,4; Z = 5.0; k = 33), BA 46 (42, 30, 10; Z = 4.8; k = 38) and BA 47 (42,26,1; Z = 4.4, k = 46). Therefore, a substantial part of Brodmann's Areas 45/47 are activated above baseline. Additionally activated voxels were located in the insula (k = 22), the middle frontal gyrus (k = 45) and the superior temporal gyrus (k = 3).

ISSN: 1471-2377