Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration

Table 1 Demographic and clinical characteristics according to Apolipoprotein E genotype.

Variable	ApoE ε4- (n = 35)	ApoE ε4+ (n = 17)	Normal data^	p ^‡
Age, years	67.1 ± 9.3	68.0 ± 6.9	-	.73
Gender, female%	51.4%	64.7%	-	.37^†
Education, years	7.7 ± 4.2	6.9 ± 2.7	-	.99
Family History, %	17.1	17.6	-	.88
Age at onset, years	64.6 ± 8.8	65.0 ± 6.9	-	.96
Estimated disease duration, years	2.6 ± 2.2	2.3 ± 1.2	-	.94
MMSE	25.3 ± 3.9	24.4 ± 4.5	24	.54
UPDRS-III	14.7 ± 11.4	10.6 ± 10.9	0	.15
IADL, lost functions	1.2 ± 1.9	2.2 ± 2.2	0	.16
BADL, lost functions	0.6 ± 1.1	0.7 ± 1.1	0	.33
Short Story	10.1 ± 4.2	6.3 ± 3.9	7.5	.004
Rey Figure, copy	27.3 ± 6.7	23.7 ± 9.2	29	.15
Rey Figure, recall	12.5 ± 5.5	10.9 ± 7.5	15	.21
Raven Coloured Matrices	24.6 ± 5.5	19.0 ± 7.0	17.5	.003
Verbal Fluency	25.1 ± 10.7	20.6 ± 10.4	16	.13
Set Test	31.0 ± 9.3	26.6 ± 9.6	24	.13
Digit Span	5.6 ± 1.4	5.4 ± 1.7	3.75	.70
Token Test	30.2 ± 4.3	27.1 ± 5.4	29	.06
Trail Making A, ES = 0 or 1	41.0%	66.0%	>1	.48^†
Trail Making B, ES = 0 or 1	50.0%	73.0%	>1	.44^†
De Renzi Imitation Test	64.3 ± 12.2	66.1 ± 9.0	62	.94

ApoE: Apolipoprotein E; MMSE: Mini-Mental State Examination; UPDRS: Unified Parkinson Disease Rating Scale; IADL: Instrumental Activities of Daily Living; BADL: Basic Activities of Daily Living; ES: Equivalent Score. Neuropsychological test scores were corrected for age and education; ^ defined according to available Italian normative data. ‡ Mann-Whitney test; † Chi-Sqare test. Results are expressed as percentage or mean ± Standard Deviation. The significant level was set at p < 0.05.