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Table 2 Concentrations of the cerebrospinal fluid (CSF) markers in CJD

From: Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?

CSF marker

median (range)

reference cut-off*

NSE (n = 57)

70 (9–200) ng/ml

12.5 ng/ml

tau (n = 56)

6764 (3772–27770) pg/ml

195 pg/ml

phosphorylated tau (n = 33)

55 (18.4–138) pg/ml

61 pg/ml

14-3-3 (n = 51)

984 (410–5387) ng/ml

200 ng/ml

S 100b (n = 54)

8 (1.4–39.2) ng/ml

2 ng/ml

PrP (n = 45)

15.7 (1–40.9) ng/100ml

22 ng/100ml

Aβ1–42

467 (143–959) pg/ml

849 pg/ml

  1. *: data were taken according to the manufacturers instruction in cases where commercially developed kits are available, otherwise calculated based on results from non-neurological controls from our study (14-3-3 and PrP)