Table 3 Severity of lesion and concentrations of CSF markers (correlation coefficient): Spongiform changes
From: Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?
| Â | Cortical regions | Subcortical regions | Cerebellum | ||||||
|---|---|---|---|---|---|---|---|---|---|
|  | CG° | MFG° | ITG° | IPG° | AS° | Putamen | Caudate ncl. | MDT° |  |
NSE | 0.0709 | 0.0731 | -0.0351 | -0.0485 | -0.0267 | 0.164 | 0.14 | 0.305* | 0.034 |
Tau | -0.173 | -0.313* | -0.219 | -0.309* | -0.217 | -0.0158 | -0.0963 | 0.024 | 0.239 |
Tau phosphorylated | -0.302 | -0.0729 | -0.227 | -0.440* | -0.195 | -0.0431 | 0.0466 | 0.282 | 0.375 |
14-3-3 | -0.142 | -0.0968 | -0.275 | -0.317 | -0.198 | 0.0631 | 0.190 | 0.246 | 0.179 |
S 100b | -0.0686 | -0.0459 | -0.303* | -0.282 | -0.359* | 0.0893 | 0.0864 | 0.242 | -0.005 |
PrP | -0.276 | -0.0955 | -0.307 | -0.364* | -0.335* | 0.0109 | -0.0289 | 0.00314 | 0.451* |
Aβ 1–42 | -0.453* | -0.233 | -0.560* | -0.356* | -0.426* | -0.159 | -0.248 | 0.0489 | 0.465* |