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Table 4 Severity of lesion and concentrations of CSF markers (correlation coefficient): Neuronal loss

From: Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?

 

Cortical regions

Subcortical regions

Cerebellum

 

CG°

MFG°

ITG°

IPG°

AS°

Putamen

Caudate ncl.

MDT°

 

NSE

0.0183

-0.0846

0.0428

-0.0769

-0.0586

0.216

0.216

-0.114

0.202

Tau

-0.233

-0.229

-0.159

-0.276

-0.158

0.121

0.0516

-0.257

-0.140

Tau phosphorylated

-0.216

-0.236

-0.337

-0.454*

-0.505*

-0.128

-0.130

-0.235

-0.058

14-3-3

-0.146

-0.170

-0.103

-0.154

-0.118

0.0184

0.0698

-0.266

-0.127

S 100b

-0.169

-0.203

-0.192

-0.344*

-0.282*

0.195

0.199

-0.254

-0.0115

PrP

-0.240

-0.219

-0.457*

-0.318

-0.511*

-0.260

-0.144

-0.159

-0.279

Aβ 1–42

-0.386

-0.295

-0.661*

-0.315

-0.488*

-0.387

-0.302

-0.321

-0.0136

  1. ° MDT: medio-dorsal thalamus
  2. CG: cingulate gyrus
  3. MFG: medial frontal gyrus
  4. ITG: inferior temporal gyrus
  5. IPG: inferior parietal gyrus
  6. AS: area striata
  7. * significant, p ≤ 0.05