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Table 2 Results Summary

From: Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

  TRPV1 TRPV3 TRPV4 TRPM8
Nerve injury Increased (brachial plexus) Increased (brachial plexus) Positive Unchanged Positive. Reduced
Hypersensitive skin Increased Not detected Fibres Unchanged Positive Increased?
DRG injury Decreased (see Smith et al 2002) Decreased (see Smith et al 2002) Positive Unchanged Co-localise with TRPV1/TRPV3 Positive Unchanged
Diabetic skin Decreased fibres Negative keratinocytes Nerve fibres not detected Trend for decreased keratinocytes Positive fibres – very few Positive Unchanged
Neuropathic nerve Positive fibres Decreased None detected Not examined Positive Unchanged
Spinal cord Positive dorsal horn Positive motor neurones Positive weak motor neurones Weak fibres in dorsal horn and roots
Dorsal roots Positive fibres Not detected Positive fibres Positive fibres
Ventral roots Not detected Positive fibres Positive fibres Positive fibres
  1. TRPV: Transient Receptor Potential Vanilloid; TRPM: Transient Receptor Potential Melastatin; DRG: Dorsal Root Ganglion.