| TRPV1 | TRPV3 | TRPV4 | TRPM8 |
---|---|---|---|---|
Nerve injury | Increased (brachial plexus) | Increased (brachial plexus) | Positive Unchanged | Positive. Reduced |
Hypersensitive skin | Increased | Not detected | Fibres Unchanged | Positive Increased? |
DRG injury | Decreased (see Smith et al 2002) | Decreased (see Smith et al 2002) | Positive Unchanged Co-localise with TRPV1/TRPV3 | Positive Unchanged |
Diabetic skin | Decreased fibres Negative keratinocytes | Nerve fibres not detected Trend for decreased keratinocytes | Positive fibres – very few | Positive Unchanged |
Neuropathic nerve | Positive fibres Decreased | None detected | Not examined | Positive Unchanged |
Spinal cord | Positive dorsal horn | Positive motor neurones | Positive weak motor neurones | Weak fibres in dorsal horn and roots |
Dorsal roots | Positive fibres | Not detected | Positive fibres | Positive fibres |
Ventral roots | Not detected | Positive fibres | Positive fibres | Positive fibres |