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Table 2 Results Summary

From: Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

 

TRPV1

TRPV3

TRPV4

TRPM8

Nerve injury

Increased (brachial plexus)

Increased (brachial plexus)

Positive Unchanged

Positive. Reduced

Hypersensitive skin

Increased

Not detected

Fibres Unchanged

Positive Increased?

DRG injury

Decreased (see Smith et al 2002)

Decreased (see Smith et al 2002)

Positive Unchanged Co-localise with TRPV1/TRPV3

Positive Unchanged

Diabetic skin

Decreased fibres Negative keratinocytes

Nerve fibres not detected Trend for decreased keratinocytes

Positive fibres – very few

Positive Unchanged

Neuropathic nerve

Positive fibres Decreased

None detected

Not examined

Positive Unchanged

Spinal cord

Positive dorsal horn

Positive motor neurones

Positive weak motor neurones

Weak fibres in dorsal horn and roots

Dorsal roots

Positive fibres

Not detected

Positive fibres

Positive fibres

Ventral roots

Not detected

Positive fibres

Positive fibres

Positive fibres

  1. TRPV: Transient Receptor Potential Vanilloid; TRPM: Transient Receptor Potential Melastatin; DRG: Dorsal Root Ganglion.