Table 4 Antibody index results of MS patients. AI > 1.4 is indicative of intrathecal synthesis of virus-specific IgG. Qualitative differences between the semi-automated method and the 8-point-standard curve method on the BEP2000 are underlined. Qualitative differences between the 4-point-standard curve method (BEP2000) and the other two methods are shown in bold face and italics

1

1.37

2.7

neg.²

9.5

neg.

3.7

neg.

11.0

neg.

4.0

neg.

11.4

neg.

2

1.31

1.7

1.6

17.5

0.4

1.6

1.8

15.2

0.6

1.4

1.9

20.3

1.2

3

1.08

3.1

0.7

1.6

0.5

2.9

0.9

1.4

0.7

1.9

0.8

1.2

0.7

4

0.87

5.9

0.7

11.9

1.9

7.7

0.8

10.5

2.0

1.3

0.7

10.3

1.1

5

1.18

42.2

6.9

1.8

3.0

24.7

9.7

3.1

2.4

22.1

11.6

2.7

2.2

6

1.36

5.9

14.3

9.4

neg.

6.1

14.5

9.3

neg.

4.9

12.6

8.8

neg.

7

1.88

43.4

0.8

2.2

neg.

35.8

1.6

3.5

neg.

29.4

1.3

2.0

neg.

8

1.15

2.6

2.9

1.0

0.5

3.2

2.5

1.0

0.7

4.1

2.6

0.8

0.5

9

1.08

2.8

1.2

0.6

0.6

5.9

3.9

1.7

0.7

n. d. ³

n. d.

n. d.

n. d.

10

0.73

2.5

1.6

1.5

2.1

2.0

1.4

0.8

1.2

2.6

1.2

0.8

0.9

11

3.19

11.8

3.7

1.6

neg.

5.0

3.1

1.6

neg.

3.7

2.6

1.2

neg.

12

0.99

6.3

3.4

7.6

0.7

9.0

2.8

2.9

0.6

n. d.

n. d.

n. d.

n. d.

13

0.98

1.1

2.2

2.3

1.2

1.1

5.8

1.4

0.9

n. d.

n. d.

n. d.

n. d.

14

1.78

1.3

9.5

1.9

neg.

1.2

12.0

3.3

neg.

1.4

10.4

3.7

neg.

15

2.20

4.4

1.8

4.1

neg.

3.5

1.8

3.4

neg.

3.5

1.6

2.9

neg.

16

2.27

3.0

2.6

n. a.⁴

2.1

4.5

4.2

3.4

3.3

3.2

3.2

3.0

1.6

17

1.21

7.0

4.5

0.9

0.4

5.3

4.0

1.0

0.7

8.4

5.8

0.9

0.6

18

4.23

10.1

44.7

10.7

1.0

8.8

37.4

10.4

0.9

9.1

41.7

10.5

1.0

19

2.78

12.3

11.0

17.5

0.9

7.1

11.4

19.1

1.0

7.7

13.6

19.3

1.0

20

2.04

5.7

3.8

1.9

2.6

8.6

5.8

2.2

1.6

8.9

5.2

2.1

1.9

21

2.65

2.1

4.2

3.4

7.1

2.3

3.0

5.3

5.8

1.9

1.8

3.6

5.7

22

0.98

11.4

1.5

2.5

1.2

5.3

1.9

2.4

1.2

6.4

1.9

2.3

1.0