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Table 1 First symptom of Charcot-Marie-Tooth disease.

From: Two novel connexin32 mutations cause early onset X-linked Charcot-Marie-Tooth disease

Family member Sex Age at onset years First symptom
Family 1
III-7 6 Muscle cramps, thin legs, problems going skiing and skating
IV-4 3 Muscle cramps, problems with running and reduced balance
IV-8 10 Problems with running and skating and reduced balance
IV-12 6 Problems with running and excessive falling
IV-15 22 Excessive tiredness
V-4 7 Problems with running and skiing
Family 2
III-2 6 Muscle cramps, problems with running and reduced balance
IV-1 4 Weakness in lower extremities, problems with running and walking and reduced balance
IV-3 11 Weakness in lower extremities, problems with running and walking and reduced balance
V-1 1 Reduced balance and problems with walking