All patients | ADAS-Cog | ADAS-Cog | ADAS-Cog | |
---|---|---|---|---|
(n = 95) | improved | no change | worsened | |
(n = 19) | (n = 53) | (n = 23) | ||
Baseline characteristics | ||||
Females, n (%) | 68 (72) | 15 (79) | 36 (68) | 17 (74) |
Age, mean years (sd) | 75.8 (7.7) | 79.8 (8.2) | 75.5 (6.3) | 73.3 (8.9) |
Education, mean years (sd) | 11.1 (3.2) | 10.5 (3.2) | 11.0 (3.2) | 11.6 (3.2) |
Duration of illness, mean years (sd) | 1.3 (1.5) | 1.0 (1.0) | 1.3 (1.7) | 1.5 (1.6) |
CDR = mild, n (%) | 73 (77) | 14 (74) | 44 (83) | 15 (65) |
Baseline outcomes | ||||
CIBIS+, mean (sd) | 3.7 (0.8) | 3.7 (0.8) | 3.6 (0.7) | 3.9 (0.7) |
MMSE, mean (sd) | 19.9 (5.3) | 20.0 (4.7) | 20.6 (5.3) | 18.3 (5.4) |
ADAS-Cog, mean (sd) | 24.6 (9.9) | 26.4 (10.6) | 23.2 (9.3) | 26.3 (10.4) |
PSMS, mean (sd) | 8.8 (2.5) | 9.3 (2.1) | 8.8 (2.7) | 8.3 (2.2) |
IADL, mean (sd) | 19.9 (5.4) | 20.5 (4.6) | 20.1 (5.4) | 18.9 (6.1) |
CSD, mean (sd) | 5.7 (5.4) | 6.4 (5.5) | 5.5 (5.1) | 5.9 (6.2) |
Treatment goals set at baseline | ||||
PGAS-total, mean (sd) | 8.6 (3.3) | 8.2 (2.7) | 8.7 (3.3) | 8.6 (3.8) |
PGAS-cognition, mean (sd)1 | 1.2 (0.8) | 1.1 (0.7) | 1.2 (0.8) | 1.2 (0.7) |
CGAS-total, mean (sd) | 3.4 (1.3) | 3.1 (0.8) | 3.5 (1.4) | 3.3 (1.2) |
CGAS-cognition, mean (sd)2 | 2.1 (1.8) | 2.5 (2.3) | 2.2 (1.7) | 1.8 (1.4) |