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Table 1 Methodological aspects of all included trials.

From: Meta-analysis of the literature on diagnostic accuracy of SPECT in parkinsonian syndromes

Author

Number of patients (exclusive controls) (1)

Study methodology (2)

Patiënt selection consequetive

Golden standard (3)

Clinical daignostic criteria clearly described?

Minimal duration follow-up after scan (month)

Radiotracer: pre- or postsynaptic or both

Name of radiotracer (4)

SPECT judged visually, template or drawn (5)

Part of striatum judged (6)

Cut-off point of 2 sd's taken by the authors?

Drug stopped appropriate before SPECT? (7)

SPECT judged blindly for clinical diagnoses?

Asenbaum '98

61

II, III

-

cc

yes

-

pre

beta

m

striatum

2sd

yes

yes

Benamer '00

185

II

-

cc

yes

-

pre

fpcit

t

striatum

-

yes

yes

Booij '01

20

I

-

cf

yes

24

pre

fpcit

t

striatum

2sd

-

yes

Buck '95

23

II

-

cc

yes

-

post

ibf

t

striatum

2sd

-

-

Eerola '05

135

I

yes

cf

yes

24

pre

beta

m

striatum

-

yes

-

Gerschlager '02

33

II

-

cc

yes

-

pre

beta

m

striatum

-

yes

-

Haapaniemi '01

29

III

-

cf

yes

24

pre

beta

t

striatum

-

yes

yes

Huang '01

34

III

-

cc

yes

-

pre

beta

m

putamen

-

yes

-

Kim '02

31

II

-

cc

yes

-

both

beta/ibf

t

c-putamen

-

yes

yes

Laere V '04

62

III

yes

.

-

.

pre

fp/tr

t

c-putamen

-

yes

-

Lee '99

26

II

-

cc

yes

-

pre

ipt

m

striatum

-

yes

-

Lokkegaard '02

72

I

yes

cf

yes

14

pre

beta

t

striatum

-

-

yes

Lu '04

85

II

-

cc

yes

-

pre

trodat

t

c-putamen

-

-

yes

Messa '98

18

II

-

cc

yes

-

pre

beta

m

c-pc

-

-

-

Muller '98

24

III

-

dd

yes

-

pre

beta

m

striatum

-

yes

yes

Oertel '93

67

II

-

fd

-

3

post

ibzm

t

striatum

2sd

yes

-

Oyanagi '02

13

II

-

cc

yes

-

post

ibf

t

striatum

-

yes

-

Pirker '97

19

II

-

cc

yes

-

post

epide

m

striatum

-

yes

-

Pirker '00

78

II

-

cc

yes

-

pre

beta

m

striatum

-

yes

-

Pirker '02

51

II

-

cc

yes

-

pre

beta

m

striatum

-

yes

yes

Plotkin '05

57

II

yes

cc

yes

-

both

fp/ibzm

t

putamen

-

yes

yes

Rooyen v '93

21

II

-

cc

-

-

posr

ibzm

m

striatum

-

yes

-

Schelvsky '93

44

II

yes

dd

-

-

post

ibzm

t

striatum

-

-

-

Schwarz '98

65

I

-

fd

yes

24

post

ibzm

t

striatum

2sd

yes

yes

Schwarz '94

20

II

-

cc

-

-

post

ibzm

t

striatum

-

-

-

Schwarz '00

28

III

-

dd

yes

-

pre

ipt

t

striatum

-

-

-

Schwarz '97

55

I

-

fd

-

24

post

ibzm

t

striatum

2sd

-

yes

Schwarz '93

62

I

yes

fd

-

4

post

ibzm

m

striatum

2sd

yes

yes

Seppi '04

32

II

yes

cc

yes

-

post

ibzm

m

striatum

2sd

yes

-

Stoffers '05

70

I

-

cf

yes

36

pre

beta

t

c-pc

2sd

yes

-

Tatsch '91

42

II

-

cc

-

-

post

ibzm

t

striatum

2sd

yes

-

Vlaar '06

147

I

yes

cf

yes

3

both

fp/ibzm

t

putamen

2sd

yes

yes

  1. - means "no" or information not clearly mentioned by the authors
  2. 1) Number of patients of particular studied included in meta-analysis. Healthy controls and patients with diseases not relevant or inconclusive diagnosis for this study are not counted.
  3. 2) Study methodology
  4. I = patients with diagnostic uncertainty. Diagnostic accuracy of SPECT was determined with a surrogate gold standard
  5. II = cross sectional study of already diagnosed patient categories
  6. III = early PD vs. normalcy
  7. 3) cf = clinical criteria after follow-up
  8. cc = clinical criteria without follow-up
  9. dd = effect dopaminergic drugs or apomorphine test
  10. fd = clinical criteria after follow-up & effect dopaminergic drugs or apomorphine test
  11. 4) beta = Iodine-123-beta-CIT (beta-CIT), fpcit = Iodine-123-Ioflupane (FP-CIT), tr = Iodine-123-IPT and 99mCT-TRODAT-1.
  12. ibzm = 123I-iodobenzamide (IBZM), ibf = Iodine-123-Iodobenzofuran (IBF), epide = Iodine-123-epidepride.
  13. 5) t = region of interest determined with template
  14. m = region of interest manually encircled
  15. 6) bg = basale ganglia or striatum, put = putamen, cp = contralateral putamen, cpc = contralateral putamen/caudate ratio
  16. 7) Yes if: drugs with interference with radiotracer were stopped appropriately or if the subjects did not use dopaminergic drugs at the moment of the spect.
  17. (-) if this information was not given or if dopaminergic drugs seemed not to be stopped appropriately.