TY - JOUR AU - White, Peter D. AU - Sharpe, Michael C. AU - Chalder, Trudie AU - DeCesare, Julia C. AU - Walwyn, Rebecca AU - the PACE trial group PY - 2007 DA - 2007/03/08 TI - Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy JO - BMC Neurology SP - 6 VL - 7 IS - 1 AB - Chronic fatigue syndrome (CFS, also called myalgic encephalomyelitis/encephalopathy or ME) is a debilitating condition with no known cause or cure. Improvement may occur with medical care and additional therapies of pacing, cognitive behavioural therapy and graded exercise therapy. The latter two therapies have been found to be efficacious in small trials, but patient organisations' surveys have reported adverse effects. Although pacing has been advocated by patient organisations, it lacks empirical support. Specialist medical care is commonly provided but its efficacy when given alone is not established. This trial compares the efficacy of the additional therapies when added to specialist medical care against specialist medical care alone. SN - 1471-2377 UR - https://doi.org/10.1186/1471-2377-7-6 DO - 10.1186/1471-2377-7-6 ID - White2007 ER -