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Table 3 Characteristics Associated with Medication Nonpersistence at Six Months in the 420 Patients Enrolled in the Stroke Outcome Study from 2001–2002 at the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

From: Medication Persistence Rates and Factors Associated with Persistence in Patients Following Stroke: A Cohort Study

Characteristic Antihypertensive Antithrombotic Antilipidemic
  Not Persistenta Unadj OR Adj OR Not Persistenta Unadj OR Adj OR Not Persistenta Unadj OR Adj OR
Stroke Cohort 21/384 (5.5)    20/405 (4.9)    22/307 (7.2)   
Age (years)          
   < 65 7/112 (6.3) 0.42 (0.16, 1.13) 0.37 (0.13, 1.03) 9/130 (6.9) 0.82 (0.29, 2.29) 0.92 (0.32, 2.65) Not significant   
   65–79 3/192 (1.6) 0.10 (0.03, 0.37) 0.11 (0.03, 0.39) 4/191 (2.1) 0.24 (0.07, 0.83) 0.23 (0.06, 0.81)    
   ≥ 80 11/80 (13.8) 1.00 1.00 7/84 (8.3) 1.00 1.00    
Total medications prescribedb   0.80 (0.65, 0.995)   Not significant    Not significant   
Monthly drug costsc          
   < $90.00 7/78 (9.0) 7.05 (1.43, 34.81) 6.74 (1.32, 34.46) Not significant    Not significant   
   $90.00 – $199.99 12/161 (7.5) 5.76 (1.27, 26.18) 5.25 (1.14, 24.25)       
   ≥ $200.00 2/145 (1.4) 1.00 1.00       
OHS impairment before stroke          
   Independent Not significant    17/390 (4.4) 1.00 1.00 Not significant   
   Dependent     3/15 (20.0) 5.49 (1.41, 21.27) 7.01 (1.66, 29.58)    
OHS impairment at discharge          
   Independent Not significant    11/318 (3.5) 1.00   Not significant   
   Dependent     9/87 (10.3) 3.22 (1.29, 8.04)     
Tobacco use before stroke          
   Yes Not significant    Not significant    5/23 (21.7) 4.35 (1.44, 13.13) 4.35 (1.44, 13.13)
   No        17/283 (6.0) 1.00 1.00
History of previous stroke          
   Yes Not significant    Not significant    1/76 (1.3) 0.13 (0.02, 1.004)  
   No        21/230 (9.1) 1.00  
  1. Unadj OR = Unadjusted odds ratio (95% confidence interval); Adj OR = adjusted odds ratio (95% confidence interval); OHS = Oxford Handicap Scale
  2. aDefined as not continuing to take a medication in the same drug category from discharge to six months, values expressed as number (%)
  3. bIncludes all prescription and non-prescription medications ordered by a physician at time of discharge
  4. cIncludes only community prescription drug costs at time of discharge excluding pharmacist's professional fees