| | |
Number of
|
Percent with
| | |
|---|
|
Antidepressant
|
Outcome
|
Trials
|
Patients
|
Placebo
|
Active
|
Relative benefit (95% CI)
|
NNT (95% CI)
|
|---|
|
Duloxetine 60/120 mg
|
at least 50% pain relief
|
3
|
1,024
|
27
|
47
|
1.7 (1.4 to 2.1)
|
5.1 (3.9 to 7.3)
|
|
Amitriptyline all doses
|
global improvement
|
10
|
588
|
32
|
64
|
2.0 (1.6 to 2.4)
|
3.2 (2.6 to 4.2)
|
|
Other antidepressants
|
global improvement
|
3
|
216
|
12
|
50
|
4.2 (2.5 to 7.0)
|
2.6 (2.0 to 3.7)
|
|
Venlafaxine all doses
|
global improvement
|
3
|
200
|
25
|
57
|
2.3 (1.6 to 3.4)
|
3.1 (2.2 to 5.1)
|
|
Desipramine all doses
|
global improvement
|
2
|
78
|
10
|
59
|
5.8 (2.2 to 15)
|
2.1 (1.5 to 3.3)
|
|
Imipramine all doses
|
global improvement
|
2
|
58
|
5
|
97
|
19 (3.9 to 89)
|
1.1 (1.0 to 1.2)
|
- NNT – Number need to treat
