Table 2 Summary of efficacy in antidepressant meta-analysis
| Â | Â | Number of | Percent with | Â | Â | ||
|---|---|---|---|---|---|---|---|
Antidepressant | Outcome | Trials | Patients | Placebo | Active | Relative benefit (95% CI) | NNT (95% CI) |
Duloxetine 60/120 mg | at least 50% pain relief | 3 | 1,024 | 27 | 47 | 1.7 (1.4 to 2.1) | 5.1 (3.9 to 7.3) |
Amitriptyline all doses | global improvement | 10 | 588 | 32 | 64 | 2.0 (1.6 to 2.4) | 3.2 (2.6 to 4.2) |
Other antidepressants | global improvement | 3 | 216 | 12 | 50 | 4.2 (2.5 to 7.0) | 2.6 (2.0 to 3.7) |
Venlafaxine all doses | global improvement | 3 | 200 | 25 | 57 | 2.3 (1.6 to 3.4) | 3.1 (2.2 to 5.1) |
Desipramine all doses | global improvement | 2 | 78 | 10 | 59 | 5.8 (2.2 to 15) | 2.1 (1.5 to 3.3) |
Imipramine all doses | global improvement | 2 | 58 | 5 | 97 | 19 (3.9 to 89) | 1.1 (1.0 to 1.2) |