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Figure 2 | BMC Neurology

Figure 2

From: Pedigree with frontotemporal lobar degeneration – motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9

Figure 2

The neuropathology of patients III:2 and III:3. (A) Severe pyramidal neuronal loss from CA1 region Ammon's horn (III:2). (B) Temporal neocortex showing Aβ immunopositive plaques and cerebrovascular amyloidosis (III:2). Positive staining with ubiquitin (C-F) and TDP-43 (G-I) antibodies of neuronal cytoplasmic inclusions (NCI) in the granule cells of the dentate gyrus. Ubiquitin-positive neuronal cytoplasmic inclusions in III:2 (C, E and F) and in III:3 (D). TDP-43 positive neuronal cytoplasmic inclusions in III:2 (G and I) and III:3 (H). Bar = 50 μm in A and B; 20 μm in C and G; 10 μm in D, E, F, H and I.

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