| |
Genotypes
|
|---|
| |
ε2/ε2
|
ε2/ε3
|
ε2/ε4
|
ε3/ε3
|
ε3/ε4
|
ε4/ε4
|
|---|
|
Odds Ratio (376 AD patients; 561 control individuals)
|
0.7
|
0.9
|
3.2
|
1
|
4.2
|
12.9
|
|
CI
|
0.01–7.57
|
0.51–1.41
|
1.67–6.18
|
Ref
|
2.98–5.89
|
6.64–26.68
|
|
p value
|
1.00
|
0.62
|
< 0.001
| |
< 0.001
|
< 0.001
|
|
Odds Ratio, AD patients with no family history of dementia (n = 149)
|
1.1*
|
0.7
|
2.8
|
1
|
2.9
|
8.1
|
|
CI
|
0.00–0.16
|
0.34–1.47
|
1.17–6.44
|
Ref
|
1.83–4.58
|
3.53–19.18
|
|
p value
|
1.00
|
0.47
|
0.021
| |
< 0.001
|
< 0.000
|
|
Odds Ratio, AD patients with first degree relative with dementia (n = 213)
|
1.7
|
1.0
|
4.0
|
1
|
5.9
|
18.7
|
|
CI
|
0.03–17.27
|
0.47–1.89
|
1.79–8.86
|
Ref
|
3.88–9.15
|
8.97–41.40
|
|
p value
|
1.0
|
1.0
|
< 0.001
| |
< 0.001
|
< 0.001
|
- SD = Standard Deviation
- CI = 95% confidence interval
- Ref = Reference category
- *The Median unbiased estimate is given, since the Maximum Likelihood estimate does not exist.
