
Genotypes



ε2/ε2

ε2/ε3

ε2/ε4

ε3/ε3

ε3/ε4

ε4/ε4


Odds Ratio (376 AD patients; 561 control individuals)

0.7

0.9

3.2

1

4.2

12.9

CI

0.01–7.57

0.51–1.41

1.67–6.18

Ref

2.98–5.89

6.64–26.68

p value

1.00

0.62

< 0.001
 
< 0.001

< 0.001

Odds Ratio, AD patients with no family history of dementia (n = 149)

1.1*

0.7

2.8

1

2.9

8.1

CI

0.00–0.16

0.34–1.47

1.17–6.44

Ref

1.83–4.58

3.53–19.18

p value

1.00

0.47

0.021
 
< 0.001

< 0.000

Odds Ratio, AD patients with first degree relative with dementia (n = 213)

1.7

1.0

4.0

1

5.9

18.7

CI

0.03–17.27

0.47–1.89

1.79–8.86

Ref

3.88–9.15

8.97–41.40

p value

1.0

1.0

< 0.001
 
< 0.001

< 0.001

 SD = Standard Deviation
 CI = 95% confidence interval
 Ref = Reference category
 *The Median unbiased estimate is given, since the Maximum Likelihood estimate does not exist.