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Table 3 Odds Ratio for AD in all genotypes in patients with/without first degree relatives with dementia

From: APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

  Genotypes
  ε2/ε2 ε2/ε3 ε2/ε4 ε3/ε3 ε3/ε4 ε4/ε4
Odds Ratio (376 AD patients; 561 control individuals) 0.7 0.9 3.2 1 4.2 12.9
CI 0.01–7.57 0.51–1.41 1.67–6.18 Ref 2.98–5.89 6.64–26.68
p value 1.00 0.62 < 0.001   < 0.001 < 0.001
Odds Ratio, AD patients with no family history of dementia (n = 149) 1.1* 0.7 2.8 1 2.9 8.1
CI 0.00–0.16 0.34–1.47 1.17–6.44 Ref 1.83–4.58 3.53–19.18
p value 1.00 0.47 0.021   < 0.001 < 0.000
Odds Ratio, AD patients with first degree relative with dementia (n = 213) 1.7 1.0 4.0 1 5.9 18.7
CI 0.03–17.27 0.47–1.89 1.79–8.86 Ref 3.88–9.15 8.97–41.40
p value 1.0 1.0 < 0.001   < 0.001 < 0.001
  1. SD = Standard Deviation
  2. CI = 95% confidence interval
  3. Ref = Reference category
  4. *The Median unbiased estimate is given, since the Maximum Likelihood estimate does not exist.