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Table 1 Disease characteristics of monofocal vs multifocal CIS patients

From: MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome

  All Monofocal Multifocal p-value*
N 468 (100%) 246 (53%) 222 (47%)  
Sex – % of females 71% 66% 76% 0.0325
Age, median
(quartiles)
30
(24–37)
29
(24–37)
31
(25–37)
0.0820
Steroid treatment – % 71% 72% 70% 0.6835
EDSS (screening), median (quartiles) 2
(1–2.5)
1.5
(1–2)
2
(1.5–2.5)
< 0.0001
CSF positive of samples taken – % 267/314
85% (57%)
149/176
85% (61%)
118/138
86% (53%)
0.8745
Number of T2 lesions, median (quartiles) 17
(7–38)
16
(6–36)
21
(8–41)
0.0182
At least one Gd-enhancing lesion – % 42% 42% 43% 0.9254
At least one T1 hypointense lesion – % 68% 63% 73% 0.0300
  1. *Compares monofocal vs. multifocal patients. P-value in bold when p ≤ 0.05
  2. Fisher's exact test
  3. Mann-Whitney U-test
  4. EDSS: expanded disability status scale
  5. CSF: cerebrospinal fluid
  6. Gd: gadolinium