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Table 2 Disease course of monofocal vs. multifocal placebo patients after the CIS

From: MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome

  All Monofocal Multifocal p-value*
N 176 93 83  
CDMS %* over 2 years 45% 47% 44% 0.7052†
Median annualized cumulative number of NALs over the study (quartiles) 3.2
(0.96–10.4) 		3.0
(0.5–9.4) 		3.6
(1.0–12.5) 		0.4698‡
  1. *Compares monofocal vs. multifocal patients
  2. NAL: newly active lesion
  3. CDMS: clinically definite MS
  4. † Kaplan-Meier estimate at day 720, Log rank test
  5. ‡Wilcoxon test
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