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Table 4 Disease course of multifocal placebo patients by symptoms and by signs after the CIS

From: MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome

 

All multifocal

Multifocal by symptoms

Multifocal by signs

p-value*

N

83

50 (60%)

33 (40%)

 

CDMS %* over 2 years

44%

49%

37%

0.3554†

Median annualized cumulative number of NALs over the study (quartiles)

3.6

(1.0–12.5)

5.3

(1.6–13.4)

2.6

(0–7.0)

0.0424‡

  1. *Compares multifocal patients by symptoms vs. multifocal patients by signs
  2. †Kaplan-Meier estimate at day 720, Log rank test
  3. ‡Wilcoxon test
  4. CDMS: clinically definite MS
  5. NAL: newly active lesion
  6. Gd: gadolinium
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BMC Neurology

ISSN: 1471-2377

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