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Figure 3 | BMC Neurology

Figure 3

From: Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen

Figure 3

Frataxin depletion impaired ISC-enzymes activities. ISC-proteins activities in frataxin-deficient R2 clones (R2C1 and R2C2) and non-transfected control cell line. As the data was equivalent, data of both frataxin deficient clones were pooled for representation. SCCR (succinate cytochrome c reductase, respiratory chain complex II) and aconitases (Aco) are ISC proteins while COX (cytochrome c oxidase, respiratory chain complex IV) and IDH (isocitrate dehydrogenase) do not contain an ISC.

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