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Table 1 Oxidative stress, antioxidant biomarkers and S-100B protein levels in the serum and CSF of the studied group

From: Oxidative stress and S-100B protein in children with bacterial meningitis

Mediators

Patients

(n = 40)

Controls

(n = 20)

 

CSF

Serum

CSF/serum

ratio (10-3)

Index

Serum

Albumin* (g/dl)

     

mean ± 2SD

1.27 ± 0.08

2.53 ± 0.41

513.78 ± 80.87

-

3.94 ± 1.03

Range

1.10-1.51

2.09-3.21

395.64-604.03

 

2.27-5.40

Significance

 

p < 0.0001

   

NO (nmol/ml)

     

mean ± 2SD

16.21 ± 1.73

23.02 ± 7.90

927.34 ± 190.69

1.86 ± 0.54

14.64 ± 2.41

Range

13.49-21.55

15.08-45.95

898.03-1453.96

1.25-2.94

10.73-20.62

Significance

 

p < 0.01

   

LPO (μmol/l)

     

mean ± 2SD

14.49 ± 1.13

17.89 ± 2.56

825.48 ± 134.26

1.66 ± 0.42

6.78 ± 1.00

Range

12.54-15.88

12.38-22.85

642.89-1205.17

1.08-2.50

5.40-8.10

Significance

 

p < 0.0001

   

Total Thiol (nmol/ml)

     

mean ± 2SD

0.56 ± 0.20

6.10 ± 2.55

24.11 ± 9.39

0.05 ± 0.02

1.13 ± 0.34

Range

0.28-1.25

1.63-10.66

9.06-41.39

0.02-0.1

0.79-1.80

Significance

 

p < 0.0001

   

SOD (U/g protein)

     

mean ± 2SD

2.87 ± 1.06

3.30 ± 1.20

122.75 ± 52.70

0.24 ± 0.11

1.08 ± 0.20

Range

49.34-2077.48

1.22-6.97

40.43-298.06

0.08-0.62

0.78-1.34

Significance

 

p < 0.0001

   

S100 B (ng/ml)

     

mean ± 2SD

0.61 ± 0.05

0.22 ± 0.13

2772.73 ± 188.48

-

0.13 ± 0.02

Range

0.55-0.70

0.13-0.57

1228.07-4230.77

 

0.11-0.16

Significance

 

p < 0.05

   
  1. One-way ANOVA or *Mann-Whitney U tests were used for comparison between different groups
  2. CSF: cerebrospinal fluid; NO: nitric oxide; LPO: lipid peroxide; SOD: superoxide dismutase
  3. Albumin ratio = [albumin CSF level] × 103
  4. [albumin serum level]
  5. Mediator ratio = [mediator CSF level] × 103
  6. [mediator serum level]
  7. Mediator index = [mediator CSF level]/[mediator serum level] [albumin CSF level]/[albumin serum level]
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BMC Neurology

ISSN: 1471-2377

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