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Table 2 Comparison between the serum and CSF concentrations of oxidative stress, antioxidant biomarkers and S-100B protein among patients with positive and negative CSF culture for bacteria

From: Oxidative stress and S-100B protein in children with bacterial meningitis

Mediators

Patients with positive bacterial culture (n = 15)

Patients with negative bacterial culture (n = 25)

 

CSF

serum

CSF/serum

ratio (10-3)

Index

CSF

serum

CSF/serum

ratio (10-3)

Index

Albumin* (g/dl)

1.27 ± 0.06

2.50 ± 0.50

526.01 ± 113.21

-

1.29 ± 0.10

2.55 ± 0.43

523.45 ± 109.36

-

Significance

p > 0.05

p >0.05

p > 0.05

     

NO (nmol/ml)

15.75 ± 1.06

28.55 ± 12.30

694.15 ± 175.22

1.37 ± 0.42

17.24 ± 3.27

23.36 ± 7.77

731.35 ± 194.58

1.44 ± 0.44

Significance

p > 0.05

p < 0.01

p > 0.05

p > 0.05

    

LPO (umol/l)

17.53 ± 3.2

24.31 ± 4.98

741.02 ± 152.27

1.47 ± 0.41

17.79 ± 3.51

24.54 ± 6.41

767.36 ± 217.24

1.53 ± 0.53

Significance

p > 0.05

p > 0.05

p > 0.05

p > 0.05

    

Total Thiol (nmol/ml)

0.63 ± 0.27

6.09 ± 3.07

26.78 ± 11.35

0.05 ± 0.03

0.52 ± 0.13

6.11 ± 2.25

22.51 ± 7.81

0.04 ± 0.02

Significance

p < 0.01

p > 0.05

p > 0.05

p < 0.05

    

SOD (U/g protein)

3.21 ± 1.22

3.89 ± 1.36

133.08 ± 49.53

0.26 ± 0.12

2.66 ± 0.91

2.94 ± 0.94

116.55 ± 54.54

0.23 ± 0.11

Significance

p > 0.05

p > 0.05

p > 0.05

p > 0.05

    

S100 B (ng/ml)

0.61 ± 0.38

0.70 ± 0.21

945.97 ± 687.62

-

0.66 ± 0.11

0.58 ± 0.42

844.21 ± 555.64

-

Significance

p > 0.05

p < 0.05

p > 0.05

     
  1. One-way ANOVA or *Mann-Whitney U tests were used for comparison between different groups CSF: cerebrospinal fluid; NO: nitric oxide; LPO: lipid peroxide; SOD: superoxide dismutase