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Table 3 Comparison between the serum and CSF concentrations of oxidative stress, antioxidant biomarkers and S-100B protein among patients with and without neurological complications

From: Oxidative stress and S-100B protein in children with bacterial meningitis

Mediators

Patients with neurological complications (n = 7)

Patients without neurological complications (n = 35)

 

CSF

serum

CSF/serum

ratio (10-3)

Index

CSF

serum

CSF/serum

ratio (10-3)

Index

Albumin* (g/dl)

1.35 ± 0.05

2.55 ± 0.43

529.41 ± 94.55

-

1.27 ± 0.43

2.45 ± 0.45

518.37 ± 112.6

-

Significance

p > 0.05

p > 0.05

p > 0.05

     

NO (nmol/ml)

18.41 ± 1.42

29.70 ± 12.03

620.69 ± 176.07

1.17 ± 0.47

10.91 ± 2.87

22.38 ± 9.68

487.49 ± 190.37

0.94 ± 0.22

Significance

p < 0.05

p < 0.05

p < 0.05

p < 0.05

    

LPO (umol/l)

13.64 ± 2.68

20.24 ± 6.11

673.90 ± 150.47

1.26 ± 0.40

11.70 ± 3.49

28.14 ± 5.84

415.77 ± 200.30

0.80 ± 0.05

Significance

p < 0.05

p < 0.05

p < 0.01

p < 0.05

    

Total Thiol (nmol/ml)

0.69 ± 0.32

6.04 ± 3.07

31.87 ± 12.31

0.07 ± 0.03

0.53 ± 0.16

6.11 ± 2.51

22.74 ± 8.27

0.04 ± 0.02

Significance

p > 0.05

p > 0.05

p > 0.05

p > 0.05

    

SOD (U/g protein)

3.47 ± 1.30

4.35 ± 1.96

157.47 ± 56.66

0.34 ± 0.11

2.76 ± 0.99

3.11 ± 0.93

116.62 ± 50.37

0.23 ± 0.11

Significance

p > 0.05

p < 0.01

p > 0.05

p > 0.05

    

S100 B (ng/ml)

0.67 ± 0.42

0. 24 ± 0.07

2791.67 ± 754.77

-

0.25 ± 0.40

0.15 ± 0.16

1666.67 ± 573.2

-

Significance

p < 0.01

P < 0.01

p < 0.001

     
  1. One-way ANOVA or *Mann-Whitney U tests were used for comparison between different groups
  2. CSF: cerebrospinal fluid; NO: nitric oxide; LPO: lipid peroxide; SOD: superoxide dismutase