Table 5 Indirect comparison results: duloxetine vs. pregabalin.
Outcome | Indirect treatment comparison (δ) Mean (median) | 95% CI for δ | Between-study variance (τ 2) Mean (median) | 95% CI for τ 2 |
|---|---|---|---|---|
Efficacy | ||||
Reduction in 24-hour pain intensity | -0.248 (0.248) | (-0.667;0.162) | 0.052 (0.024) | (0.001;0.252) |
Response | 0.033 (0.034) | (-0.393;0.451) | 0.075 (0.052) | (0.001;0.287) |
PGI-I/PGI-C | 0.542 (0.545) | (0.016;1.060) | 0.025 (0.009) | (0.001;0.151) |
Tolerability | ||||
Premature study discontinuation due to: | ||||
- Lack of efficacy | -0.251 (-0.235) | (-1.288;0.717) | 0.058 0.015) | (0.001;0.381) |
- Adverse events | 0.152 (0.154) | (-0.505;0.790) | 0.039 (0.012) | (0.001;0.243) |
- Other | -0.068 (-0.069) | (-0.735;0.589) | 0.045 (0.013) | (0.001;0.281) |
Diarrhoea | 0.886 (0.885) | (-0.414; 2.183) | 0.248 (0.050) | (0.001; 1.628) |
Dizziness | -1.084 (-1.074) | (-1.903; -0.317) | 0.075 (0.020) | (0.001; 0.477) |
Headache | 0.700 (0.704) | (-0.078; 1.458) | 0.037 (0.011) | (0.001; 0.235) |
Somnolence | -0.554 (-0.552) | (-1.458; 0.328) | 0.052 (0.013) | (0.001; 0.347) |