Figure 1

Amyloid and tau CSF biomarker concentrations in the different patient groups and their interactions. Panels A-E plot concentrations of different markers for the 6 subject groups. Boxes encompass interquartile ranges with median (line) and mean ("+"), while whiskers designate 10^th to 90^th percentiles. Results of statistical analysis of these data are given in Table 2A. Panel F shows the principal component analysis (PCA) score scatter plot of subjects identified by disease grouping with the superimposed variable loadings of the biomarkers. The data in Panels A - E were used to construct a two-dimensional model along the two vectors. The individual subjects are represented by the small symbols as indicated in the key, and their placement is determined by the combination of their marker values in the model. The placement of the five variables (large symbols as indicated) gives information about how each affects the placement of the individuals in the plot, both with respect to direction along each vector axis and the relative magnitude of this effect as indicated by their distance from the origin. For example, high p-tau and low sAPPβ values contribute importantly to the position in the upper right and left quadrants, respectively. Note, however, that all variables influence where each subject is located in the plot so that the plot provides a visual representation of how the subjects are separated by the results of all five biomarkers. For more detailed information on methods, see reference [35]. Abbreviations: NA, HIV+ neuroasymptomatics; ADC, AIDS dementia complex; CNS OIs, CNS opportunistic infections; Contr y, younger HIV- controls; AD, Alzheimer's disease; Contr o, older HIV- controls.