TY - STD TI - 3rd Drug Discovery for Neurodegeneration Conference: Washington, DC; 2–3 February 2009. Presented by the Alzheimer's Drug Discovery Foundation, [http://www.worldeventsforum.com/addf/2009/program.html] UR - http://www.worldeventsforum.com/addf/2009/program.html ID - ref1 ER - TY - JOUR AU - Kaitin, K. I. PY - 2008 DA - 2008// TI - Obstacles and opportunities in new drug development JO - Clin Pharmacol Ther VL - 83 UR - https://doi.org/10.1038/sj.clpt.6100462 DO - 10.1038/sj.clpt.6100462 ID - Kaitin2008 ER - TY - JOUR AU - DiMasi, J. A. AU - Hansen, R. W. AU - Grabowski, H. G. PY - 2003 DA - 2003// TI - The price of innovation: new estimates of drug development costs JO - J Health Economics VL - 22 UR - https://doi.org/10.1016/S0167-6296(02)00126-1 DO - 10.1016/S0167-6296(02)00126-1 ID - DiMasi2003 ER - TY - JOUR AU - Kola, I. AU - Landis, J. PY - 2004 DA - 2004// TI - Can the pharmaceutical industry reduce attrition rates? JO - Nat Rev Drug Discov VL - 3 UR - https://doi.org/10.1038/nrd1470 DO - 10.1038/nrd1470 ID - Kola2004 ER - TY - JOUR AU - Honig, P. K. AU - Woosley, R. L. AU - Zamani, K. AU - Conner, D. P. AU - Cantilena, L. R. PY - 1992 DA - 1992// TI - Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin JO - Clin Pharmacol Ther VL - 52 UR - https://doi.org/10.1038/clpt.1992.135 DO - 10.1038/clpt.1992.135 ID - Honig1992 ER - TY - JOUR AU - Honig, P. K. AU - Wortham, D. C. AU - Zamani, K. AU - Conner, D. P. AU - Mullin, J. C. AU - Cantilena, L. R. PY - 1993 DA - 1993// TI - Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences JO - JAMA VL - 269 UR - https://doi.org/10.1001/jama.1993.03500120051025 DO - 10.1001/jama.1993.03500120051025 ID - Honig1993 ER - TY - BOOK PY - 1998 DA - 1998// TI - Seldane and Generic Terfenadine Withdrawn From Market ID - ref7 ER - TY - JOUR AU - Ball, P. AU - Mandell, L. AU - Niki, Y. AU - Tillotson, G. PY - 1999 DA - 1999// TI - Comparative tolerability of the newer fluoroquinolone antibacterials JO - Drug Safety VL - 21 UR - https://doi.org/10.2165/00002018-199921050-00005 DO - 10.2165/00002018-199921050-00005 ID - Ball1999 ER - TY - STD TI - US Food and Drug Administration: Public Health Advisory – Trovan (trovafloxacin/alatroflocacin mesylate); 9 June 1999. [http://www.fda.gov/cder/news/trovan/] UR - http://www.fda.gov/cder/news/trovan/ ID - ref9 ER - TY - BOOK AU - Stephens, J. PY - 2006 DA - 2006// TI - Panel Faults Pfizer in '96 Clinical Trial In Nigeria. The Washington Post 7 ID - Stephens2006 ER - TY - JOUR AU - Kubinyi, H. PY - 2003 DA - 2003// TI - Drug research: myths, hype and reality JO - Nat Rev Drug Discov VL - 2 UR - https://doi.org/10.1038/nrd1156 DO - 10.1038/nrd1156 ID - Kubinyi2003 ER - TY - JOUR AU - Schuster, D. AU - Laggner, C. AU - Langer, T. PY - 2005 DA - 2005// TI - Why drugs fail – a study on side effects in new chemical entities JO - Curr Pharm Des VL - 11 UR - https://doi.org/10.2174/138161205774414510 DO - 10.2174/138161205774414510 ID - Schuster2005 ER - TY - JOUR AU - Lipinski, C. A. AU - Lombardo, F. AU - Dominy, B. W. AU - Feeney, P. J. PY - 1997 DA - 1997// TI - Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings JO - Adv Drug Deliv Rev VL - 23 UR - https://doi.org/10.1016/S0169-409X(96)00423-1 DO - 10.1016/S0169-409X(96)00423-1 ID - Lipinski1997 ER - TY - JOUR AU - Lipinski, C. A. PY - 2000 DA - 2000// TI - Drug-like properties and the causes of poor solubility and poor permeability JO - J Pharmacol Toxicol Methods VL - 44 UR - https://doi.org/10.1016/S1056-8719(00)00107-6 DO - 10.1016/S1056-8719(00)00107-6 ID - Lipinski2000 ER - TY - JOUR AU - Schinkel, A. H. AU - Smit, J. J. AU - van Tellingen, O. AU - Beijnen, J. H. AU - Wagenaar, E. AU - van Deemter, L. AU - Mol, C. A. AU - Valk, M. A. v. a. n. d. e. r. AU - Robanus-Maandag, E. C. AU - te Riele, H. P. PY - 1994 DA - 1994// TI - Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs JO - Cell VL - 77 UR - https://doi.org/10.1016/0092-8674(94)90212-7 DO - 10.1016/0092-8674(94)90212-7 ID - Schinkel1994 ER - TY - JOUR AU - el-Bacha, R. S. AU - Minn, A. PY - 1999 DA - 1999// TI - Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain JO - Cell Mol Biol VL - 45 ID - el-Bacha1999 ER - TY - JOUR AU - Hurko, O. AU - Ryan, J. L. PY - 2005 DA - 2005// TI - Translational research in central nervous system drug discovery JO - NeuroRx VL - 2 UR - https://doi.org/10.1602/neurorx.2.4.671 DO - 10.1602/neurorx.2.4.671 ID - Hurko2005 ER - TY - JOUR AU - Liu, X. AU - Chen, C. PY - 2005 DA - 2005// TI - Strategies to optimize brain penetration in drug discovery JO - Curr Opin Drug Discov Dev VL - 8 ID - Liu2005 ER - TY - JOUR AU - Megard, I. AU - Garrigues, A. AU - Orlowski, S. AU - Jorajuria, S. AU - Clayette, P. AU - Ezan, E. AU - Mabondzo, A. PY - 2002 DA - 2002// TI - A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitrocorrelation JO - Brain Res VL - 927 UR - https://doi.org/10.1016/S0006-8993(01)03337-6 DO - 10.1016/S0006-8993(01)03337-6 ID - Megard2002 ER - TY - JOUR AU - Begley, D. J. AU - Lechardeur, D. AU - Chen, Z. D. AU - Rollinson, C. AU - Bardoul, M. AU - Roux, F. AU - Scherman, D. AU - Abbott, N. J. PY - 1996 DA - 1996// TI - Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4 JO - J Neurochem VL - 67 UR - https://doi.org/10.1046/j.1471-4159.1996.67030988.x DO - 10.1046/j.1471-4159.1996.67030988.x ID - Begley1996 ER - TY - JOUR AU - Deli, M. A. AU - Abraham, C. S. AU - Kataoka, Y. AU - Niwa, M. PY - 2005 DA - 2005// TI - Permeability studies on in vitroblood-brain barrier models: physiology, pathology and pharmacology JO - Cell Mol Neurobiol VL - 25 UR - https://doi.org/10.1007/s10571-004-1377-8 DO - 10.1007/s10571-004-1377-8 ID - Deli2005 ER - TY - JOUR AU - Crone, C. PY - 1963 DA - 1963// TI - The permeability of capillaries in various organs as determined by use of the 'indicator diffusion' method JO - Acta Physiol Scand VL - 58 UR - https://doi.org/10.1111/j.1748-1716.1963.tb02652.x DO - 10.1111/j.1748-1716.1963.tb02652.x ID - Crone1963 ER - TY - JOUR AU - Oldendorf, W. H. PY - 1970 DA - 1970// TI - Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard JO - Brain Res VL - 24 UR - https://doi.org/10.1016/0006-8993(70)90123-X DO - 10.1016/0006-8993(70)90123-X ID - Oldendorf1970 ER - TY - JOUR AU - Takasato, Y. AU - Rapoport, S. I. AU - Smith, Q. R. PY - 1984 DA - 1984// TI - An in situbrain perfusion technique to study cerebrovascular transport in the rat JO - Am J Physiol VL - 247 ID - Takasato1984 ER - TY - JOUR AU - Kakee, A. AU - Terasaki, T. AU - Sugiyama, Y. PY - 1996 DA - 1996// TI - Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier JO - J Pharmacol Exp Ther VL - 277 ID - Kakee1996 ER - TY - JOUR AU - Elmquist, W. F. AU - Sawchuk, R. J. PY - 1997 DA - 1997// TI - Application of microdialysis in pharmacokinetic studies JO - Pharm Res VL - 14 UR - https://doi.org/10.1023/A:1012081501464 DO - 10.1023/A:1012081501464 ID - Elmquist1997 ER - TY - JOUR AU - Olson, H. AU - Betton, G. AU - Robinson, D. AU - Thomas, K. AU - Monro, A. AU - Kolaja, G. AU - Lilly, P. AU - Sanders, J. AU - Sipes, G. AU - Bracken, W. AU - Dorato, M. AU - Van Deun, K. AU - Smith Berger, P. B. AU - Heller, A. PY - 2000 DA - 2000// TI - Concordance of the toxicity of pharmaceuticals in humans and in animals JO - Regul Toxicol Pharmacol VL - 32 UR - https://doi.org/10.1006/rtph.2000.1399 DO - 10.1006/rtph.2000.1399 ID - Olson2000 ER - TY - STD TI - US Food and Drug Administration: Guidance for Industry Drug Interaction Studies – Study Design, Data Analysis, and Implications for Dosing and Labeling. [http://www.fda.gov/CDER/guidance/6695dft.htm] UR - http://www.fda.gov/CDER/guidance/6695dft.htm ID - ref28 ER - TY - JOUR AU - Uetrecht, J. PY - 2008 DA - 2008// TI - Idiosyncratic drug reactions: past, present, and future JO - Chem Resin Toxicol VL - 21 UR - https://doi.org/10.1021/tx700186p DO - 10.1021/tx700186p ID - Uetrecht2008 ER - TY - JOUR AU - Josserand, V. AU - Pélerin, H. AU - de Bruin, B. AU - Jego, B. AU - Kuhnast, B. AU - Hinnen, F. AU - Ducongé, F. AU - Boisgard, R. AU - Beuvon, F. AU - Chassoux, F. AU - Daumas-Duport, C. AU - Ezan, E. AU - Dollé, F. AU - Mabondzo, A. AU - Tavitian, B. PY - 2006 DA - 2006// TI - Evaluation of drug penetration into the brain: a double study by in vivo imaging with positron emission tomography and using an in vitromodel of the human blood-brain barrier JO - J Pharmacol Exp Ther VL - 316 UR - https://doi.org/10.1124/jpet.105.089102 DO - 10.1124/jpet.105.089102 ID - Josserand2006 ER - TY - JOUR AU - Pardridge, W. M. AU - Triguero, D. AU - Yang, J. AU - Cancilla, P. A. PY - 1990 DA - 1990// TI - Comparison of in vitro and in vivomodels of drug transcytosis through the blood-brain barrier JO - J Pharmacol Exp Ther VL - 253 ID - Pardridge1990 ER - TY - JOUR AU - Jacewicz, M. AU - Guyot, A. -. C. AU - Annand, R. AU - Gilbert, J. AU - Mabondzo, A. AU - Tsaioun, K. PY - 2008 DA - 2008// TI - Contribution of transporters to permeability across cell monolayers. Comparison of three models JO - AAPS J VL - 423 ID - Jacewicz2008 ER - TY - JOUR AU - Dykens, J. A. AU - Will, Y. PY - 2007 DA - 2007// TI - The significance of mitochondrial testing in drug development JO - Drug Discov Today VL - 12 UR - https://doi.org/10.1016/j.drudis.2007.07.013 DO - 10.1016/j.drudis.2007.07.013 ID - Dykens2007 ER - TY - JOUR AU - Rodríguez-Enríquez, S. AU - Juárez, O. AU - Rodríguez-Zavala, J. S. AU - Moreno-Sánchez, R. PY - 2001 DA - 2001// TI - Multisite control of the Crabtree effect in ascites hepatoma cells JO - Eur J Biochem VL - 268 UR - https://doi.org/10.1046/j.1432-1327.2001.02140.x DO - 10.1046/j.1432-1327.2001.02140.x ID - Rodríguez-Enríquez2001 ER - TY - JOUR AU - Marroquin, L. D. AU - Hynes, J. AU - Dykens, J. A. AU - Jamieson, J. D. AU - Will, Y. PY - 2007 DA - 2007// TI - Circumventing the Crabtree effect: Replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants JO - Toxicol Sci VL - 97 UR - https://doi.org/10.1093/toxsci/kfm052 DO - 10.1093/toxsci/kfm052 ID - Marroquin2007 ER - TY - JOUR AU - Williams, D. P. AU - Park, B. K. PY - 2003 DA - 2003// TI - Idiosyncratic toxicity: the role of toxicophores and bioactivation JO - Drug Discov Today VL - 8 UR - https://doi.org/10.1016/S1359-6446(03)02888-5 DO - 10.1016/S1359-6446(03)02888-5 ID - Williams2003 ER - TY - JOUR AU - Liu, Z. X. AU - Kaplowitz, N. PY - 2006 DA - 2006// TI - Role of innate immunity in acetaminophen-induced hepatotoxicity JO - Expert Opin Drug Metab Toxicol VL - 2 UR - https://doi.org/10.1517/17425255.2.4.493 DO - 10.1517/17425255.2.4.493 ID - Liu2006 ER - TY - JOUR AU - Ademuyiwa, O. AU - Agarwal, R. AU - Chandra, R. AU - Behari, J. R. PY - 2009 DA - 2009// TI - Lead-induced phospholipidosis and cholesterogenesis in rat tissues JO - Chem Biol Interactions VL - 179 UR - https://doi.org/10.1016/j.cbi.2008.10.057 DO - 10.1016/j.cbi.2008.10.057 ID - Ademuyiwa2009 ER - TY - JOUR AU - Ekins, S. AU - Nikolsky, Y. AU - Nikolskaya, T. PY - 2005 DA - 2005// TI - Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity JO - Trends Pharmacol Sci VL - 26 UR - https://doi.org/10.1016/j.tips.2005.02.006 DO - 10.1016/j.tips.2005.02.006 ID - Ekins2005 ER - TY - JOUR AU - Natalie, M. AU - Margino, S. AU - Erik, H. AU - Annelieke, P. AU - Geert, V. AU - Philippe, V. PY - 2009 DA - 2009// TI - A 96-well flow cytometric screening assay for detecting in vitrophospholipidosis-induction in the drug discovery phase JO - Toxicol In Vitro VL - 23 UR - https://doi.org/10.1016/j.tiv.2008.11.010 DO - 10.1016/j.tiv.2008.11.010 ID - Natalie2009 ER - TY - STD TI - US Food and Drug Administration: Guidance for Industry – S2B Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals. [http://www.fda.gov/CDER/guidance/1856fnl.pdf] UR - http://www.fda.gov/CDER/guidance/1856fnl.pdf ID - ref41 ER - TY - JOUR AU - Hastwell, P. W. AU - Chai, L. -. L. AU - Roberts, K. J. AU - Webster, T. W. AU - Harvey, J. S. AU - Rees, R. W. AU - Walmsley, R. M. PY - 2006 DA - 2006// TI - High-specificity and high-sensitivity genotoxicity assessment in a human cell line: Validation of the GreenScreen HC GADD45a-GFP genotoxicity assay JO - Mutat Res VL - 607 UR - https://doi.org/10.1016/j.mrgentox.2006.04.011 DO - 10.1016/j.mrgentox.2006.04.011 ID - Hastwell2006 ER - TY - JOUR AU - Khetani, S. R. AU - Bhatia, S. N. PY - 2008 DA - 2008// TI - Microscale culture of human liver cells for drug development JO - Nat Biotechnol VL - 26 UR - https://doi.org/10.1038/nbt1361 DO - 10.1038/nbt1361 ID - Khetani2008 ER - TY - JOUR AU - Viravaidya, K. AU - Shuler, M. L. PY - 2004 DA - 2004// TI - Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies JO - Biotechnol Prog VL - 20 UR - https://doi.org/10.1021/bp034238d DO - 10.1021/bp034238d ID - Viravaidya2004 ER - TY - JOUR AU - Yang, L. AU - Soonpaa, M. H. AU - Adler, E. D. AU - Roepke, T. K. AU - Kattman, S. J. AU - Kennedy, M. AU - Henckaerts, E. AU - Bonham, K. AU - Abbott, G. W. AU - Linden, R. M. AU - Field, L. J. AU - Keller, G. M. PY - 2008 DA - 2008// TI - Human cardiovascular progenitor cells develop from a KDR+embryonic-stem-cell-derived population JO - Nature VL - 453 UR - https://doi.org/10.1038/nature06894 DO - 10.1038/nature06894 ID - Yang2008 ER - TY - JOUR AU - O'Brien, P. J. AU - Irwin, W. AU - Diaz, D. AU - Howard-Cofield, H. AU - Krejsa, C. M. AU - Slaughter, M. R. AU - Gao, B. AU - Kaludercic, N. AU - Angeline, N. AU - Bernardi, P. AU - Brain, P. AU - Hougham, C. PY - 2006 DA - 2006// TI - High concordance of drug-induced human hepatotoxicity with in vitrocytotoxicity measured in a novel cell-based model using high content screening JO - Arch Toxicol VL - 80 UR - https://doi.org/10.1007/s00204-006-0091-3 DO - 10.1007/s00204-006-0091-3 ID - O'Brien2006 ER - TY - JOUR AU - Stoughton, R. B. AU - Friend, S. H. PY - 2005 DA - 2005// TI - How molecular profiling could revolutionize drug discovery JO - Nat Rev Drug Discov VL - 4 UR - https://doi.org/10.1038/nrd1696 DO - 10.1038/nrd1696 ID - Stoughton2005 ER - TY - JOUR AU - Kaplowitz, N. PY - 2005 DA - 2005// TI - Idiosyncratic drug hepatotoxicity JO - Nat Rev Drug Discov VL - 4 UR - https://doi.org/10.1038/nrd1750 DO - 10.1038/nrd1750 ID - Kaplowitz2005 ER -