MRI findings. Cerebral MRI in subject II-2 (A-C), III-2 (G-I) and IV-4 and spinal MRI in subject III-1 (D-F). (A-C): axial T2-ffe showing left ponto-mesencephalic angioma (A) and multiple supratentorial cavernous angiomas (left temporal and posterior frontal). (D-F): sagittal T1W-TSE (D-E) and sagittal T1W-TSE (F) showing multiple vertebral hemangiomas D12, L2-L5. (G-I): axial T2-ffe showing right pontine (G) and parietal (H) angiomas. Axial SWI (I) with abnormal right parietal and bilateral frontal venous malformations. (J-L) axial T2-ffe (J-K): multiple bilateral cerebral angiomas with involvement of the splenium of the corpus callosum, periventricular parietal white matter, head of the caudate nucleus, bilaterally, left cortical and subcortical white matter.