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Table 1 Demographic and clinical characteristics between NMOSD without and with autoimmune diseases, and between NMOSD with non-organ-specific and organ-specific autoimmune diseases

From: Neuromyelitis optica spectrum disorders without and with autoimmune diseases

  NMOSD   NMOSD with autoimmune diseases  
Without autoimmune diseases (n = 115) With autoimmune diseases (n = 40) P Non-organ-specific (n = 22) Organ-specific (n = 18) P
Gender, F: M 91: 24 37: 3 0.055 22: 0 15: 3 0.165
Age, years 37.63 ± 14.33 40.71 ± 13.80 0.240 40.90 ± 14.86 40.47 ± 12.80 0.924
Age at onset, years 34.20 ± 13.70 37.37 ± 13.50 0.207 36.91 ± 14.63 37.94 ± 12.37 0.814
Disease duration, years 1.83 (0.08, 30.00) 1.33 (0.08, 31.08) 0.219 1.25 (0.08, 31.08) 2.67 (0.08, 7.00) 0.414
Annualized relapse rate 0.66 (0, 12.00) 0.89 (0, 6.00) 0.183 0.80 (0, 3.43) 0.95 (0, 6.00) 0.784
EDSS at last visit 2.0 (0, 23.0) 2.5 (0, 10.0) 0.067 2.5 (1.0, 8.5) 3.0 (0, 10.0) 0.529
Clinical features, n (%)       
Headache 18 (15.7%) 8 (20.0%) 0.526 3 (13.6%) 5 (27.8%) 0.475
Nystagmus 6 (5.2%) 4 (10.0%) 0.289 2 (9.1%) 2 (11.1%) 0.832
IHN 26 (22.6%) 12 (30.0%) 0.349 4 (18.2%) 8 (44.4%) 0.071
Bulbar paralysis 9 (7.8%) 2 (5.0%) 0.549 1 (4.5%) 1 (5.6%) 1.000
Bowel or bladder dysfunction 49 (42.6%) 18 (45.0%) 0.793 7 (31.8%) 11 (61.1%) 0.064
Visual impairment 98 (85.2%) 33 (82.5%) 0.682 18 (81.8%) 15 (83.3%) 0.900
Motor deficit 68 (59.1%) 21 (52.5%) 0.465 8 (36.4%) 13 (72.2%) 0.024*
Sensory deficit 83 (72.2%) 25 (62.5%) 0.252 14 (63.6%) 11 (61.1%) 0.870
Neuropathic pain 29 (25.4%) 13 (32.5%) 0.388 6 (27.3%) 7 (38.9%) 0.435
  1. Abbreviations: EDSS Expanded Disability Status Scale, F: M female: male, IHN intractable hiccup and nausea, NMOSD neuromyelitis optica spectrum disorders.
  2. *p < 0.05.