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Table 3 MRI features between NMOSD without and with autoimmune diseases, and between NMOSD with non-organ-specific and organ-specific autoimmune diseases

From: Neuromyelitis optica spectrum disorders without and with autoimmune diseases

  NMOSD   NMOSD with autoimmune diseases  
Without autoimmune diseases (n = 115) With autoimmune diseases (n = 40) P Non-organ-specific (n = 22) Organ-specific (n = 18) P
Brain lesions, n (%) 77 (67.0%) 40 (100.0%) <0.001** 22 (100.0%) 18 (100.0%) -
Brain lobes 50 (43.5%) 23 (57.5%) 0.126 12 (54.5%) 11 (61.1%) 0.676
Basal ganglia 15 (13.0%) 8 (20.0%) 0.286 6 (27.3%) 2 (11.1%) 0.382
Hypothalamic and thalamic 12 (10.4%) 2 (5.0%) 0.302 1 (4.5%) 1 (5.6%) 1.000
Ventricle and aqueduct 21 (18.3%) 10 (25.0%) 0.359 4 (18.2%) 6 (33.3%) 0.463
Midbrain 5 (4.2%) 2 (5.0%) 0.864 1 (4.5%) 1 (4.5%) 1.000
Pons 14 (12.2%) 9 (22.5%) 0.114 4 (18.2%) 5 (27.8%) 0.732
Medulla oblongata 29 (25.2%) 13 (32.5%) 0.372 5 (22.7%) 8 (44.4%) 0.145
Cerebellum 8 (7.0%) 1 (2.5%) 0.299 1 (4.5%) 0 (00.0%) 1.000
Spinal cord lesions, n (%) 88 (76.5%) 32 (80.0%) 0.650 17 (77.3%) 15 (83.3%) 0.634
Segments lesions 5 (0, 17) 6 (0, 15) 0.486 4 (0, 17) 6.5 (0, 15) 0.603
LETM 81 (70.4%) 28 (70.0%) 0.959 14 (63.6%) 14 (77.8%) 0.332
Cervical cord 74 (64.3%) 27 (67.5%) 0.719 12 (54.5%) 15 (83.3%) 0.053
Thoracic cord 62 (53.9%) 26 (65.0%) 0.223 14 (63.6%) 12 (66.7%) 0.842
Cervical and thoracic cord 48 (41.7%) 23 (57.5%) 0.085 11 (50.0%) 12 (66.7%) 0.289
  1. Abbreviations: LETM longitudinally extensive transverse myelitis, MRI magnetic resonance imaging, NMOSD neuromyelitis optica spectrum disorders.
  2. **p < 0.001.