Table 3 MRI features between NMOSD without and with autoimmune diseases, and between NMOSD with non-organ-specific and organ-specific autoimmune diseases
From: Neuromyelitis optica spectrum disorders without and with autoimmune diseases
NMOSD | NMOSD with autoimmune diseases | |||||
|---|---|---|---|---|---|---|
Without autoimmune diseases (n = 115) | With autoimmune diseases (n = 40) | P | Non-organ-specific (n = 22) | Organ-specific (n = 18) | P | |
Brain lesions, n (%) | 77 (67.0%) | 40 (100.0%) | <0.001** | 22 (100.0%) | 18 (100.0%) | - |
Brain lobes | 50 (43.5%) | 23 (57.5%) | 0.126 | 12 (54.5%) | 11 (61.1%) | 0.676 |
Basal ganglia | 15 (13.0%) | 8 (20.0%) | 0.286 | 6 (27.3%) | 2 (11.1%) | 0.382 |
Hypothalamic and thalamic | 12 (10.4%) | 2 (5.0%) | 0.302 | 1 (4.5%) | 1 (5.6%) | 1.000 |
Ventricle and aqueduct | 21 (18.3%) | 10 (25.0%) | 0.359 | 4 (18.2%) | 6 (33.3%) | 0.463 |
Midbrain | 5 (4.2%) | 2 (5.0%) | 0.864 | 1 (4.5%) | 1 (4.5%) | 1.000 |
Pons | 14 (12.2%) | 9 (22.5%) | 0.114 | 4 (18.2%) | 5 (27.8%) | 0.732 |
Medulla oblongata | 29 (25.2%) | 13 (32.5%) | 0.372 | 5 (22.7%) | 8 (44.4%) | 0.145 |
Cerebellum | 8 (7.0%) | 1 (2.5%) | 0.299 | 1 (4.5%) | 0 (00.0%) | 1.000 |
Spinal cord lesions, n (%) | 88 (76.5%) | 32 (80.0%) | 0.650 | 17 (77.3%) | 15 (83.3%) | 0.634 |
Segments lesions | 5 (0, 17) | 6 (0, 15) | 0.486 | 4 (0, 17) | 6.5 (0, 15) | 0.603 |
LETM | 81 (70.4%) | 28 (70.0%) | 0.959 | 14 (63.6%) | 14 (77.8%) | 0.332 |
Cervical cord | 74 (64.3%) | 27 (67.5%) | 0.719 | 12 (54.5%) | 15 (83.3%) | 0.053 |
Thoracic cord | 62 (53.9%) | 26 (65.0%) | 0.223 | 14 (63.6%) | 12 (66.7%) | 0.842 |
Cervical and thoracic cord | 48 (41.7%) | 23 (57.5%) | 0.085 | 11 (50.0%) | 12 (66.7%) | 0.289 |