Skip to main content

Table 3 Patients characteristics at time of thrombolysis and 24 hours after thrombolysis

From: Mobilization after thrombolysis (rtPA) within 24 hours of acute stroke: what factors influence inclusion of patients in A Very Early Rehabilitation Trial (AVERT)?

Variable potAVERT (n = 105) AVERT (n = 50) Effect size* (95%CI) p
Stroke to needle (min)       
Median (IQR) 138 (108–156) 126 (108–156) −1.2 (−15-13.2) 0.88
NIHSS       
At 24 hours       
Median (IQR) 5.5 (2–12) 8.5 (5–14) 2 (0–5) 0.04
Physiological data at thrombolysis       
Hypertension 31 (62%) 66 (63%) 0.96 (0.48-1.92) >0.99
Hypotension 0 0 1 (2.0%) N/A 0.32
Hyperglycaemia 3 (3.3%) 2 (4.6%) 1.41 (0–7.38) 0.66
Hypoglycaemia 0 0 2 (4.6%) N/A 0.10
Bradycardia 13 (12%) 10 (20%) 1.77 (0.73-4.30) 0.23
Tachycardia 9 (8.6%) 4 (8.0%) 0.93 (0.29-3.01) >0.99
Arythmia 24 (25%) 15 (33%) 1.48 (0.69-3.18) 0.32
Rapid atrial fibrillation 5 (4.9%) 3 (6.0%) 1.24 (0.31-4.92) 0.72
Hypoxia 1 (1.0%) 0 0 N/A >0.99
Complications at 24 h post thrombolysis       
Hemorrhagic transformation 14 (13%) 10 (20%) 1.63 (0.68-3.91) 0.34
sICH 0 0 1 (2.0%) N/A 0.32
Bleeding other than cerebral 12 (11%) 3 (6.0%) 0.49 (0.14-1.7) 0.39
DVT 1 (1.0%) 1 (2.0%) 2.12 (0) 0.54
Infection 9 (8.6%) 6 (12%) 1.45 (0.51-4.19) 0.56
  1. *Effect sizes expressed as H-L for continuous and OR for binary.
  2. Hypertension is defined as a blood pressure (BP) > 140/90 mmHg; hypotension: BP < 90/60 mmHg; hyperglycaemia; blood sugar level (BSL) > 13.5 mmol/L; hypoglycaemia: BSL < 4.0 mmol/L; bradycardia: heart rate < 60 beats per minute (bpm); tachycardia > 100 bpm; hypoxia: O2 saturation < 90%.