Increased risk of hip fractures in patients with dementia: a nationwide population-based study

BMC Neurology

Table 2 Fracture risk among sampled patients during the 3-year follow-up period from index health care utilization (N = 8,448)

	Patients with dementia N = 1408		Alzheimer disease N = 183		Unspecific dementia N = 1225		Comparison patients N = 7040
Fracture occurrence	N.	%	N.	%	N.	%	N.	%
Total	264	18.75	38	20.77	226	18.45	1098	15.60
Crude HR (95% CI)	1.37* (1.19- 1.57)		1.40* (1.18-1.61)		1.36* (1.13-1.67)		1.00
Adjusted HR (95% CI)	1.34* (1.14- 1.58)		1.37* (1.13-1.59)		1.33* (1.11-1.63)		1.00
Hip fracture	109	7.74	17	9.29	92	7.51	306	4.35
Crude HR (95% CI)	2.03* (1.63- 2.52)		2.31* (1.57- 2.76)		2.01* (1.49- 2.93)		1.00
Adjusted HR (95% CI)	1.92* (1.48- 2.49)		2.19* (1.43- 2.88)		1.87* (1.33- 2.83)		1.00
Wrist fracture	47	3.34	7	3.83	40	3.27	177	2.51
Crude HR (95% CI)	1.43 (0.92- 2.04)		1.55 (0.95- 2.61)		1.16 (0.88- 2.74)		1.00
Adjusted HR (95% CI)	1.66 (0.97- 2.55)		1.49 (0.98- 2.57)		1.34 (0.91- 2.88)		1.00
Vertebral fracture	93	6.61	14	7.65	79	6.45	548	7.78
Crude HR (95% CI)	0.99 (0.79- 1.23)		1.00 (0.83- 1.31)		0.91 (0.72- 1.78)		1.00
Adjusted HR (95% CI)	0.88 (0.67- 1.14)		0.92 (0.69- 1.22)		0.88 (0.62- 1.53)		1.00

*P < 0.05. HR, hazard ratio; CI, confidence interval. Hazard ratios were calculated with the stratified Cox proportional regression method (stratified by sex, age group, and the year of index health care use) during the 3-year follow-up period. Adjustments were made for Charlson Comorbidity Index in the patients.

ISSN: 1471-2377