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Table 3 Analysis of association between stroke severity (NIHSS) and ten APOD and SIGMAR1 SNPs

From: Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

  NIHSS score   NIHSS; dichotomous indicator of medium-severe (vs. mild) ischemic stroke onset (NIHSS ≥ 8) NIHSS; dichotomous indicator of severe (vs. mild-medium) ischemic stroke onset (NIHSS ≥ 16)
Simple logistic regression Multiple logistic regression Simple logistic regression Multiple logistic regression
SNP Estimated Spearman’s Rho P-value OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
SIGMAR1:           
rs11559048 0.023 0.284 1.86 (0.44-7.79) 0.399 1.74 (0.40-7.69) 0.462 --*) -- --*) --
rs1800866 -0.012 0.554 1.02 (0.87-1.22) 0.772 0.98 (0.81-1.17) 0.804 0.97 (0.75-1.25) 0.822 0.87 (0.64-1.17) 0.347
rs12001648 -0.044 0.040 0.77 (0.56-1.05) 0.094 0.65 (0.46-0.91) 0.012 1.01 (0.66-1.56) 0.967 0.75 (0.48-1.27) 0.283
rs7036351 0.000 0.984 1.04 (0.87-1.25) 0.670 0.99 (0.81-1.21) 0.922 0.94 (0.71-1.25) 0.664 0.84 (0.61-1.16) 0.290
rs3808873 0.011 0.627 1.04 (0.88-1.23) 0.619 1.07 (0.90-1.27) 0.457 0.79 (0.61-1.03) 0.084 0.77 (0.57-1.03) 0.079
APOD:           
rs76929107 0.004 0.826 0.85 (0.50-1.46) 0.555 0.74 (0.40-1.36) 0.327 0.97 (0.45-2.12) 0.948 1.17 (0.50-2.73) 0.722
rs5952 0.022 0.309 1.54 (0.38-6.18) 0.542 1.40 (0.34-5.79) 0.641 --*) -- --*) --
rs34697430 0.011 0.599 1.07 (0.93-1.23) 0.334 1.08 (0.94-1.25) 0.280 1.16 (0.95-1.42) 0.154 1.20 (0.96-1.50) 0.116
rs7659 -0.048 0.023 0.89 (0.77-1.04) 0.141 0.85 (0.72-1.00) 0.044 0.84 (0.66-1.06) 0.135 0.70 (0.54-0.92) 0.009
rs823510 0.013 0.538 1.03 (0.88-1.21) 0.680 1.00 (0.85-1.19) 0.965 1.06 (0.83-1.34) 0.658 0.96 (0.73-1.25) 0.736
  1. Ischemic stroke patients from Lund Stroke Register and the Sahlgenska Academy Study on Ischaemic Stroke.
  2. NIHSS = NIH stroke scale. *) Cannot be estimated due to monomorphism among patients with NIHSS score of 16 or above.