Table 3 Analysis of association between stroke severity (NIHSS) and ten APOD and SIGMAR1 SNPs
NIHSS score | NIHSS; dichotomous indicator of medium-severe (vs. mild) ischemic stroke onset (NIHSS ≥ 8) | NIHSS; dichotomous indicator of severe (vs. mild-medium) ischemic stroke onset (NIHSS ≥ 16) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Simple logistic regression | Multiple logistic regression | Simple logistic regression | Multiple logistic regression | |||||||
SNP | Estimated Spearman’s Rho | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value |
SIGMAR1: | ||||||||||
rs11559048 | 0.023 | 0.284 | 1.86 (0.44-7.79) | 0.399 | 1.74 (0.40-7.69) | 0.462 | --*) | -- | --*) | -- |
rs1800866 | -0.012 | 0.554 | 1.02 (0.87-1.22) | 0.772 | 0.98 (0.81-1.17) | 0.804 | 0.97 (0.75-1.25) | 0.822 | 0.87 (0.64-1.17) | 0.347 |
rs12001648 | -0.044 | 0.040 | 0.77 (0.56-1.05) | 0.094 | 0.65 (0.46-0.91) | 0.012 | 1.01 (0.66-1.56) | 0.967 | 0.75 (0.48-1.27) | 0.283 |
rs7036351 | 0.000 | 0.984 | 1.04 (0.87-1.25) | 0.670 | 0.99 (0.81-1.21) | 0.922 | 0.94 (0.71-1.25) | 0.664 | 0.84 (0.61-1.16) | 0.290 |
rs3808873 | 0.011 | 0.627 | 1.04 (0.88-1.23) | 0.619 | 1.07 (0.90-1.27) | 0.457 | 0.79 (0.61-1.03) | 0.084 | 0.77 (0.57-1.03) | 0.079 |
APOD: | ||||||||||
rs76929107 | 0.004 | 0.826 | 0.85 (0.50-1.46) | 0.555 | 0.74 (0.40-1.36) | 0.327 | 0.97 (0.45-2.12) | 0.948 | 1.17 (0.50-2.73) | 0.722 |
rs5952 | 0.022 | 0.309 | 1.54 (0.38-6.18) | 0.542 | 1.40 (0.34-5.79) | 0.641 | --*) | -- | --*) | -- |
rs34697430 | 0.011 | 0.599 | 1.07 (0.93-1.23) | 0.334 | 1.08 (0.94-1.25) | 0.280 | 1.16 (0.95-1.42) | 0.154 | 1.20 (0.96-1.50) | 0.116 |
rs7659 | -0.048 | 0.023 | 0.89 (0.77-1.04) | 0.141 | 0.85 (0.72-1.00) | 0.044 | 0.84 (0.66-1.06) | 0.135 | 0.70 (0.54-0.92) | 0.009 |
rs823510 | 0.013 | 0.538 | 1.03 (0.88-1.21) | 0.680 | 1.00 (0.85-1.19) | 0.965 | 1.06 (0.83-1.34) | 0.658 | 0.96 (0.73-1.25) | 0.736 |