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Table 4 Detailed assessment of possible association between stroke severity (NIHSS) and SNP rs7659 within APOD

From: Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

 

NIHSS score

 

NIHSS; dichotomous indicator of medium-severe (vs. mild) ischemic stroke onset (NIHSS ≥ 8)

NIHSS; dichotomous indicator of severe (vs. mild-medium) ischemic stroke onset (NIHSS ≥ 16)

Subgroup

Estimated Spearman’s Rho

P-value

Simple logistic regression

Multiple logistic regression

Simple logistic regression

Multiple logistic regression

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Total

-0.048

0.023

0.89 (0.77-1.04)

0.141

0.85 (0.72-1.00)

0.044

0.84 (0.66-1.06)

0.135

0.70 (0.54-0.92)

0.009

(N = 2221)

  

1676 controls

 

1618 controls

 

2023 controls

 

1947 controls

 
   

545 cases

 

495 cases

 

198 cases

 

166 cases

 

Males

-0.055

0.053

0.89 (0.72-1.11)

0.293

0.85 (0.68-1.06)

0.143

0.82 (0.58-1.17)

0.273

0.75 (0.52-1.10)

0.144

(N = 1232)

  

971 controls

 

939 controls

 

1146 controls

 

1105 controls

 
   

261 cases

 

243 cases

 

86 cases

 

77 cases

 

Females

-0.040

0.209

0.90 (0.73-1.11)

0.311

0.85 (0.68-1.07)

0.168

0.85 (0.62-1.16)

0.311

0.66 (0.46-0.96)

0.028

(N = 989)

  

705 controls

 

679 controls

 

877 controls

 

842 controls

 
   

284 cases

 

252 cases

 

112 cases

 

89 cases

 

LSR

-0.054

0.026

0.87 (0.73-1.03)

0.113

0.81 (0.67-0.98)

0.026

0.79 (0.61-1.03)

0.081

0.65 (0.48-0.88)

0.005

(N = 1683)

  

1263 controls

 

1204 controls

 

1523 controls

 

1450 controls

 
   

420 cases

 

377 cases

 

160 cases

 

133 cases

 

SAHLSIS

-0.032

0.454

0.97 (0.71-1.33)

0.858

0.94 (0.68-1.30)

0.702

1.03 (0.62-1.73)

0.902

0.86 (0.48-1.53)

0.605

(N = 538)

  

413 controls

 

412 controls

 

500 controls

 

497 controls

 
   

125 cases

 

118 cases

 

38 cases

 

33 cases

 

Age < 70

-0.066

0.029

0.89 (0.70-1.13)

0.333

0.85 (0.67-1.09)

0.201

0.98 (0.66-1.47)

0.940

0.81 (0.51-1.27)

0.348

(N = 1084)

  

868 controls

 

853 controls

 

1021 controls

 

1001 controls

 
   

216 cases

 

202 cases

 

63 cases

 

54 cases

 

Age ≥ 70

-0.042

0.156

0.88 (0.72-1.08)

0.215

0.82 (0.66-1.02)

0.080

0.76 (0.57-1.01)

0.060

0.63 (0.45-0.88)

0.006

(N = 1137)

  

808 controls

 

750 controls

 

1002 controls

 

946 controls

 
   

329 cases

 

266 cases

 

135 cases

 

112 cases

 

LVD

-0.008

0.918

1.14 (0.70-1.87)

0.597

0.97 (0.57-1.66)

0.924

1.20 (0.54-2.67)

0.651

0.53 (0.17-1.65)

0.272

(N = 185)

  

133 controls

 

128 controls

 

170 controls

 

163 controls

 
   

52 cases

 

45 cases

 

15 cases

 

10 cases

 

SVD

-0.019

0.667

0.77 (0.46-1.30)

0.329

0.81 (0.47-1.38)

0.432

N/A

 

N/A

 

(N = 500)

  

461 controls

 

452 controls

     
   

39 cases

 

38 cases

     

CE

-0.076

0.065

0.89 (0.70-1.15)

0.367

0.78 (0.59-1.03)

0.081

0.72 (0.52-1.00)

0.051

0.59 (0.40-0.85)

0.005

(N = 595)

  

364 controls

 

338 controls

 

484 controls

 

448 controls

 
   

231 cases

 

204 cases

 

111 cases

 

94 cases

 
  1. Ischemic stroke patients from Lund Stroke Register (LSR) and the Sahlgenska Academy Study on Ischemic Stroke (SAHLSIS).
  2. NIHSS = NIH stroke scale. Multiple logistic regression models are controlling for covariates age, gender, diabetes mellitus, hypertension and current smoking when analyzing the entire sample as well as separate study groups and age groups. When analyzing males and females separately the covariate gender is omitted from these multivariable models. Pathogenetic ischemic stroke subtype: LVD = Large vessel disease; SVD = Small vessel disease; CE = Cardioembolic stroke. N/A = not applicable due to absence of sampling units with NIHSS ≥ 16.
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BMC Neurology

ISSN: 1471-2377

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