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Table 4 Detailed assessment of possible association between stroke severity (NIHSS) and SNP rs7659 within APOD

From: Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

  NIHSS score   NIHSS; dichotomous indicator of medium-severe (vs. mild) ischemic stroke onset (NIHSS ≥ 8) NIHSS; dichotomous indicator of severe (vs. mild-medium) ischemic stroke onset (NIHSS ≥ 16)
Subgroup Estimated Spearman’s Rho P-value Simple logistic regression Multiple logistic regression Simple logistic regression Multiple logistic regression
OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
Total -0.048 0.023 0.89 (0.77-1.04) 0.141 0.85 (0.72-1.00) 0.044 0.84 (0.66-1.06) 0.135 0.70 (0.54-0.92) 0.009
(N = 2221)    1676 controls   1618 controls   2023 controls   1947 controls  
    545 cases   495 cases   198 cases   166 cases  
Males -0.055 0.053 0.89 (0.72-1.11) 0.293 0.85 (0.68-1.06) 0.143 0.82 (0.58-1.17) 0.273 0.75 (0.52-1.10) 0.144
(N = 1232)    971 controls   939 controls   1146 controls   1105 controls  
    261 cases   243 cases   86 cases   77 cases  
Females -0.040 0.209 0.90 (0.73-1.11) 0.311 0.85 (0.68-1.07) 0.168 0.85 (0.62-1.16) 0.311 0.66 (0.46-0.96) 0.028
(N = 989)    705 controls   679 controls   877 controls   842 controls  
    284 cases   252 cases   112 cases   89 cases  
LSR -0.054 0.026 0.87 (0.73-1.03) 0.113 0.81 (0.67-0.98) 0.026 0.79 (0.61-1.03) 0.081 0.65 (0.48-0.88) 0.005
(N = 1683)    1263 controls   1204 controls   1523 controls   1450 controls  
    420 cases   377 cases   160 cases   133 cases  
SAHLSIS -0.032 0.454 0.97 (0.71-1.33) 0.858 0.94 (0.68-1.30) 0.702 1.03 (0.62-1.73) 0.902 0.86 (0.48-1.53) 0.605
(N = 538)    413 controls   412 controls   500 controls   497 controls  
    125 cases   118 cases   38 cases   33 cases  
Age < 70 -0.066 0.029 0.89 (0.70-1.13) 0.333 0.85 (0.67-1.09) 0.201 0.98 (0.66-1.47) 0.940 0.81 (0.51-1.27) 0.348
(N = 1084)    868 controls   853 controls   1021 controls   1001 controls  
    216 cases   202 cases   63 cases   54 cases  
Age ≥ 70 -0.042 0.156 0.88 (0.72-1.08) 0.215 0.82 (0.66-1.02) 0.080 0.76 (0.57-1.01) 0.060 0.63 (0.45-0.88) 0.006
(N = 1137)    808 controls   750 controls   1002 controls   946 controls  
    329 cases   266 cases   135 cases   112 cases  
LVD -0.008 0.918 1.14 (0.70-1.87) 0.597 0.97 (0.57-1.66) 0.924 1.20 (0.54-2.67) 0.651 0.53 (0.17-1.65) 0.272
(N = 185)    133 controls   128 controls   170 controls   163 controls  
    52 cases   45 cases   15 cases   10 cases  
SVD -0.019 0.667 0.77 (0.46-1.30) 0.329 0.81 (0.47-1.38) 0.432 N/A   N/A  
(N = 500)    461 controls   452 controls      
    39 cases   38 cases      
CE -0.076 0.065 0.89 (0.70-1.15) 0.367 0.78 (0.59-1.03) 0.081 0.72 (0.52-1.00) 0.051 0.59 (0.40-0.85) 0.005
(N = 595)    364 controls   338 controls   484 controls   448 controls  
    231 cases   204 cases   111 cases   94 cases  
  1. Ischemic stroke patients from Lund Stroke Register (LSR) and the Sahlgenska Academy Study on Ischemic Stroke (SAHLSIS).
  2. NIHSS = NIH stroke scale. Multiple logistic regression models are controlling for covariates age, gender, diabetes mellitus, hypertension and current smoking when analyzing the entire sample as well as separate study groups and age groups. When analyzing males and females separately the covariate gender is omitted from these multivariable models. Pathogenetic ischemic stroke subtype: LVD = Large vessel disease; SVD = Small vessel disease; CE = Cardioembolic stroke. N/A = not applicable due to absence of sampling units with NIHSS ≥ 16.