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Table 1 Univariate analysis of potential prognostic factors associated with mortality one year after first diagnosis (N = 176)

From: Factors predicting one-year mortality in amyotrophic lateral sclerosis patients - data from a population-based registry

Parameters at FD N Category Total Death during 12 months from FD Log-rank test
ob-served mis-sing n = 60 % X2(DF) p(X2)
Age 176 0 ≤ 65 69 18 26% 24.13 (2) < 0.0001
66-75 84 25 30%
> 75 23 17 74%
Gender 176 0 male 96 31 32% 0.29 (1) 0.59
female 80 29 36%
Site of onset 176 0 bulbar 62 25 40% 1.71 (1) 0.19
spinal 114 35 31%
Site of spinal onset 114 0 upper limbs 39 10 26% 2.58 (4) 0.64
lower limbs 60 20 33%
upper + lower limbs 8 3 38%
trunk 7 2 29%
DOD [months] 176 0 0 - 6 60 27 45% 9.41 (3) 0.024
07-12 61 17 28%
13-24 37 15 41%
≥ 25 18 1 6%
BMI [kg/ m 2 ] 173 3 < 25 92 34 37% 0.97 (1) 0.33
≥ 25 81 24 30%
Diff-BMI [kg/ m 2 ] 173 3 < 1 87 14 16% 33.14 (2) < 0.0001
1 - < 2 31 11 35%
≥ 2 55 33 60%
EEC 176 0 possible 31 6 19% 16.21 (3) 0.001
probable (lab. conf.) 54 12 22%
probable 63 26 41%
definite 28 16 57%
FRS 173 3 < 32 72 44 61% 46.92 (1) < 0.0001
≥ 32 101 14 14%
FVC [%] 153 23 < 80 31 19 61% 28.61 (1) < 0.0001
≥ 80 122 27 22%
PCO 2 [mm Hg] 134 42 < 42 112 33 29% 15.97 (1) < 0.0001
≥ 42 22 14 64%
CK [U/ l] 153 23 < 150 73 27 37% 1.29 (1) 0.26
≥ 150 80 24 30%
Pre-alcohol cons. status 149 27 no 62 26 42% 2.99 (1) 0.084
yes 87 19 22%
Pre-smoking status 151 25 no 85 23 27% 0.69 (1) 0.41
yes 66 23 35%
social life 153 23 living in a partnership 109 28 26% 1.59 (1) 0.21
single person 44 19 43%
Abbreviations DOD delay between onset and diagnosis FD first diagnosis
BMI body mass index FRS functional rating scale
Diff-BMI difference between BMI at diagnosis and six months before FVC forced vital capacity
   PCO2 carbondioxide pressure in blood
EEC revised El Escorial criteria CK creatinine kinase